Results 51 to 60 of about 6,413 (205)

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors.

PLoS ONE, 2019
Several novel bisbenzylisoquinoline alkaloids (BBIQAs) have recently been isolated from a Matis tribe arrow poison and shown by two-electrode voltage-clamp to inhibit mouse muscle nicotinic acetylcholine receptors (nAChR).
Ekaterina N Spirova, Igor A Ivanov, Igor E Kasheverov, Denis S Kudryavtsev, Irina V Shelukhina, Alexandra I Garifulina, Lina V Son, Sarah C R Lummis, Gonzalo R Malca-Garcia, Rainer W Bussmann, Lothar Hennig, Athanassios Giannis, Victor I Tsetlin   +12 more
doaj   +1 more source

Impact of Curarization on Pentaspline Catheter Stability During Pulsed‐Field Pulmonary Vein Ablation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 6, Page 1363-1366, June 2026.
ABSTRACT Background Pulsed field ablation (PFA) is effective for pulmonary vein isolation (PVI), but phrenic nerve stimulation during applications may induce diaphragmatic contractions and destabilize catheter positioning. This study evaluated whether neuromuscular blockade improves catheter stability.
Aymeric Menet, Suzanne Charkaluk, William Escande, Antoine Noel, Outteryck François, Corentin Chaumont, Valentine Pecriaux, Jeremy Layec, Marie Decroocq, Yves Guyomar, Vincent Colas, Sylvestre Maréchaux, Frederic Anselme, Guillaume Viart   +13 more
wiley   +1 more source

Validation of AURA‐W: An AI‐Driven 3D Imaging System Metrics for Objective Wrinkle Assessment After Botulinum Toxin Treatment

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Most clinical assessments of botulinum toxin rely on subjective observation, limiting reproducibility. The Aura 3D Imaging System combines high‐resolution photogrammetry imaging with AI analysis to provide standardized wrinkle measurements.
Fabrizio Vignoli, Maurizio Cavallini, Emanuele Bartoletti, Lukas Buchmann, Gemma Taverni   +4 more
wiley   +1 more source

Analysis of Mrgprb2 Receptor-Evoked Ca2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice

Frontiers in Immunology, 2020
Mast cells are a heterogeneous group of immune cells. The simplest and commonly accepted classification divides them in two groups according to their protease content. We have compared the action of diverse secretagogues on bone marrow derived (BMMC) and
Volodymyr Tsvilovskyy, Alejandra Solis-Lopez, Julia Almering, Christin Richter, Lutz Birnbaumer, Lutz Birnbaumer, Alexander Dietrich, Marc Freichel   +7 more
doaj   +1 more source

First‐in‐Human Dose Selection and Safety, Tolerability, Pharmacokinetics, and Immunogenicity of the Muscle‐Specific Kinase Agonist Adimanebart (ARGX‐119)

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Adimanebart (ARGX‐119), a first‐in‐class, humanized, agonistic monoclonal antibody, specifically targets and activates muscle‐specific kinase, stabilizing the neuromuscular junction, increasing muscle strength, and decreasing muscle weakness and fatigability in nonclinical, proof‐of‐concept studies.
Tonke van Bragt, Christa Kneip, Sofie Priem, Xinghong Leng, Rachelle Mutch, Sonya K. Patel, Peter Vanhoenacker, Cristina Vaghi, Sven Hoefman, Rebecca Shilling, Roeland Vanhauwaert   +10 more
wiley   +1 more source

The Biochemistry, Toxicology, and Uses of the Pharmacologically Active Phytochemicals: Alkaloids, Terpenes, Polyphenols, and Glycosides

Journal of Food and Pharmaceutical Sciences, 2019
The research focused on the biochemistry and the medicinal uses of alkaloids, terpenes, polyphenols, and glycosides. Several parts of plants such as bark, root, leaf, stem, etc. are being used to revert abnormalities back to normal, prevent illnesses, or
Chinaza Godswill Awuchi
doaj   +1 more source

Machine‐learning classification of motor unit types in the adult mouse

The Journal of Physiology, Volume 604, Issue 10, Page 3984-4008, 15 May 2026.
Abstract figure legend The goal of this study was to build an algorithm for machine‐learning classification of motor unit (MU) physiological type in the adult mouse. We made intracellular recordings of triceps surae (TS) motoneurons in anaesthetized adult mice and recorded MU isometric force and electromyographic (EMG) activity.
María de Lourdes Martínez‐Silva, Reuben M. Ahorklo, Emily J Reedich, Rebecca D. Imhoff‐Manuel, Natallia Katenka, Marin Manuel   +5 more
wiley   +1 more source

Inhibition of succinylcholine-induced increased intraocular pressure by d-tubocurarine

, 1982
The effect of prior administration of d-tubocurarine on the increased intraocular pressure associated with the use of succinylcholine was studied in 30 randomely selected human subjects, who did not have cardiopulmonary and ocular diseases preoperatively.
金鍾學.
core   +1 more source

Cyclodextrin‐Amino Acid Conjugates: Synthesis and Pharmaceutical Applications

ChemistryEurope, Volume 4, Issue 4, April 2026.
Cyclodextrins (CDs) can be combined with amino acids via host‐guest complexation or by covalent conjugation through various synthetic routes. The chemical modifications introduce structural versatility, multifunctionality, and biocompatibility, which are essential characteristics for designing effective, next‐generation pharmaceutical formulations ...
Andrea Cesari, Nicola Lomuscio, Fabio Bellina   +2 more
wiley   +1 more source

Dual nitrergic/cholinergic control of short-term plasticity of corticostriatal inputs to striatal projection neurons

Frontiers in Cellular Neuroscience, 2015
The ability of nitric oxide and acetylcholine to modulate the short-term plasticity of corticostriatal inputs was investigated using current-clamp recordings in BAC mouse brain slices. Glutamatergic responses were evoked by stimulation of corpus callosum
Craig Peter Blomeley, Sarah eCains, Enrico eBracci   +2 more
doaj   +1 more source