Results 101 to 110 of about 292,166 (345)
The Roles of β²-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance
Cancer Informatics, 2007 The antitumor drug paclitaxel stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and eventually apoptosis. Upon assembly of the α /β-tubulin heterodimer, GTP becomes bound to both the α and β-tubulin monomers.
J. Torin Huzil +3 more
doaj
Virulence, 2018 Microtubules are involved in mechanical support, cytoplasmic organization, and several cellular processes by interacting with diverse microtubule-associated proteins such as plus-end tracking proteins, motor proteins, and tubulin-folding cofactors.
Li Li Wang +4 more
doaj +1 more source
Tyrosination of α-Tubulin Controls The Initiation of Processive Dynein-Dynactin Motility
bioRxiv, 2015 Post-translational modifications (PTMs) of α/β-tubulin are believed to regulate interactions with microtubule binding proteins. A well-characterized PTM involves the removal and re-ligation of the C-terminal tyrosine on α-tubulin, but the purpose of this
R. McKenney +3 more
semanticscholar +1 more source
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Advanced Biology, EarlyView.Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
Regulation of microtubule motors by tubulin isotypes and posttranslational modifications
Nature Cell Biology, 2014 The ‘tubulin-code’ hypothesis proposes that different tubulin genes or post-translational modifications (PTMs), which mainly confer variation in the carboxy-terminal tail (CTT), result in unique interactions with microtubule-associated proteins for ...
M. Sirajuddin, L. Rice, R. Vale
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu +7 more
wiley +1 more source
Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
Nature Communications, 2017 Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functional construct of the kinesin-13 Kif2C/MCAK in an ATP-like state ...
Weiyi Wang +6 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong +15 more
wiley +1 more source
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
Nature Communications, 2016 Centrioles and cilia are microtubule-based structures, whose precise formation requires controlled cytoplasmic tubulin incorporation. How cytoplasmic tubulin is recognized for centriolar/ciliary-microtubule construction remains poorly understood ...
Xiangdong Zheng +20 more
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009 The association of tubulin with the plasma membrane comprises multiple levels of penetration into the bilayer: from integral membrane protein, to attachment via palmitoylation, to surface binding, and to microtubules attached by linker proteins to proteins in the membrane.
openaire +3 more sources