The mechanism of anaphase spindle elongation: uncoupling of tubulin incorporation and microtubule sliding during in vitro spindle reactivation. [PDF]
, 1988 To study tubulin polymerization and microtubule sliding during spindle elongation in vitro, we developed a method of uncoupling the two processes. When isolated diatom spindles were incubated with biotinylated tubulin (biot-tb) without ATP, biot-tb was ...
CANDE, W. Zacheus +2 more
core
The Roles of β²-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance
Cancer Informatics, 2007 The antitumor drug paclitaxel stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and eventually apoptosis. Upon assembly of the α /β-tubulin heterodimer, GTP becomes bound to both the α and β-tubulin monomers.
J. Torin Huzil +3 more
doaj
Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism
Journal of Cell Biology, 2015 In Chlamydomonas cilia, IFT concentrates soluble tubulin by regulating IFT train occupancy and thereby promotes elongation of axonemal microtubules.
Julie M. Craft +4 more
semanticscholar +1 more source
Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules
, 2011 We propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin.
Correia J J +8 more
core +1 more source
Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments [PDF]
, 2009 TGases (transglutaminases) are a class of calcium-dependent enzymes that catalyse the interactions between acyl acceptor glutamyl residues and amine donors, potentially making crosslinks between proteins.
Bonner, PLR +4 more
core
Writing and Reading the Tubulin Code*
Journal of Biological Chemistry, 2015 Microtubules give rise to intracellular structures with diverse morphologies and dynamics that are crucial for cell division, motility, and differentiation.
Ian Yu, C. P. Garnham, A. Roll-Mecak
semanticscholar +1 more source
Prolonging assembly through dissociation:A self assembly paradigm in microtubules
, 2011 We study a one-dimensional model of microtubule assembly/disassembly in which GTP bound to tubulins within the microtubule undergoes stochastic hydrolysis.
Bulbul Chakraborty +4 more
core +1 more source
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly
Scientific Reports, 2015 Cilia play important roles in sensing extracellular signals and directing fluid flow. Ciliary dysfunction is associated with a variety of diseases known as ciliopathies.
J. Ran +4 more
semanticscholar +1 more source
Cancer Research, 2015 Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic strategies that remain wanting.
A. Boggs +10 more
semanticscholar +1 more source
SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. [PDF]
, 2008 Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on ...
Dammermann, Alexander +3 more
core +1 more source