Results 81 to 90 of about 436,730 (400)

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]

, 2014
Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A, Chaikeeratisak, Vorrapon, Coker, Joanna KC, Erb, Marcella L, Kraemer, James A, Nonejuie, Poochit, Pogliano, Joe   +6 more
core   +2 more sources

Balancing Act: Tubulin Glutamylation and Microtubule Dynamics in Toxoplasma gondii

Microorganisms
The success of the intracellular parasite Toxoplasma gondii in invading host cells relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The T. gondii genome encodes three isoforms of both α-
Inês L. S. Delgado, João Gonçalves, Rita Fernandes, Sara Zúquete, Afonso P. Basto, Alexandre Leitão, Helena Soares, Sofia Nolasco   +7 more
doaj   +1 more source

Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

eLife, 2018
XMAP215/Stu2/Alp14 proteins accelerate microtubule plus-end polymerization by recruiting tubulins via arrays of tumor overexpressed gene (TOG) domains, yet their mechanism remains unknown.
Stanley Nithianantham, Brian D Cook, Madeleine Beans, Fei Guo, Fred Chang, Jawdat Al-Bassam   +5 more
doaj   +1 more source

Identification of novel microtubule inhibitors effective in fission yeast and human cells and their effects on breast cancer cell lines

Open Biology, 2021
Microtubules are critical for a variety of cellular processes such as chromosome segregation, intracellular transport and cell shape. Drugs against microtubules have been widely used in cancer chemotherapies, though the acquisition of drug resistance has
Jun Morishita, Paul Nurse
doaj   +1 more source

A one-dimensional moving-boundary model for tubulin-driven axonal growth [PDF]

Journal of Theoretical Biology, 358, 2014, 194-207, 2015
A one-dimensional continuum-mechanical model of axonal elongation due to assembly of tubulin dimers in the growth cone is presented. The conservation of mass leads to a coupled system of three differential equations. A partial differential equation models the dynamic and spatial behaviour of the concentration of tubulin that is transported along the ...
arxiv   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

eLife, 2015
The precise regulation of microtubule dynamics is essential during cell division. The kinesin-13 motor protein MCAK is a potent microtubule depolymerase.
Sandeep K Talapatra, Bethany Harker, Julie PI Welburn   +2 more
doaj   +1 more source

Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs

Frontiers in Physiology, 2020
There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these hydrophobic compounds interact with the Voltage Dependent Anion Channel (VDAC).
Tatiana K. Rostovtseva, María Queralt-Martín, William M. Rosencrans, Sergey M. Bezrukov   +3 more
doaj   +1 more source

Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies

Molecules, 2023
We report herein the synthesis, docking studies and biological evaluation of a series of new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues (6a-h).
Obaid Afzal, Amena Ali, Abuzer Ali, Abdulmalik Saleh Alfawaz Altamimi, Manal A. Alossaimi, Md Afroz Bakht, Salahuddin, Mubarak A. Alamri, Md. Faiyaz Ahsan, Mohamed Jawed Ahsan   +9 more
doaj   +1 more source