Results 81 to 90 of about 408,296 (185)
The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease
Cytoskeleton, 2016 Across different cell types and tissues, microtubules are assembled from highly conserved dimers of α‐ and β‐tubulin. Despite their highly similar structures, microtubules have functional heterogeneity, generated either by the expression of different ...
Soumyananda Chakraborti +4 more
semanticscholar +1 more source
The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule. [PDF]
, 2011 There has been much effort in recent years aimed at understanding the molecular mechanism by which the Dam1 kinetochore complex is able to couple microtubule depolymerization to poleward movement. Both a biased diffusion and a forced walk model have been
Barnes, Georjana +7 more
core +2 more sources
Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation
Brain Sciences, 2018 The TUBA1A gene encodes tubulin alpha-1A, a protein that is highly expressed in the fetal brain. Alpha- and beta-tubulin subunits form dimers, which then co-assemble into microtubule polymers: dynamic, scaffold-like structures that perform key functions ...
Jennifer F. Gardner +17 more
doaj +1 more source
Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin*♦
Journal of Biological Chemistry, 2016 Microtubules are polymers that cycle stochastically between polymerization and depolymerization, i.e. they exhibit “dynamic instability.” This behavior is crucial for cell division, motility, and differentiation.
Annapurna Vemu +5 more
semanticscholar +1 more source
Effects of antibodies against tubulin on the movement of reactivated sea urchin sperm flagella [PDF]
, 1980 Antibodies binding to sea urchin flagellar outer-doublet tubulin have been isolated from rabbit sera by tubulin-affinity chromatography employing electrophoretically purified tubulin as the immobilized substrate.
Asai, David J., Brokaw, Charles J.
core +1 more source
Frontiers in Physiology, 2019 Tubulin is a well-established target of microtubule-targeting agents (MTAs), a widely used class of chemotherapeutic drugs. Yet, aside from their powerful anti-cancer efficiency, MTAs induce a dose-limiting and debilitating peripheral neurotoxicity ...
Amandine Rovini
doaj +1 more source
Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
Nature Communications, 2016 Molecules that alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin, and structural biology has explained the basis of their action and permitted ...
Jianhong Yang +10 more
semanticscholar +1 more source
TUBB4B is essential for the expansion of differentiating spermatogonia
Scientific ReportsMicrotubules, polymers of αβ-tubulin heterodimers, are essential for various cellular processes. The incorporation of different tubulin isotypes, each encoded by distinct genes, is proposed to contribute to the functional diversity observed in ...
Urikhan Sanzhaeva +3 more
doaj +1 more source
Frontiers in Oncology, 2017 The voltage-dependent anion channel (VDAC) is well known as the pathway for passive diffusion of anionic hydrophilic mitochondrial metabolites across the outer membrane, but a more complex functionality of the three isoforms of VDAC has emerged, as ...
John J. Lemasters, John J. Lemasters
doaj +1 more source
The structured core of human β tubulin confers isotype-specific polymerization properties
Journal of Cell Biology, 2016 The tubulin gene family encodes multiple tubulin isotypes that can have distinct polymerization properties. Pamula et al. show that residue changes within β tubulin’s structured core are largely responsible for isotype-specific differences in dynamic ...
Melissa C Pamula, S. Ti, T. Kapoor
semanticscholar +1 more source