Results 11 to 20 of about 619,494 (287)

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi, AD Borowsky, AJ Minn, AM Havens, B Brandt, B Qian, Bin-Zhi Qian, BS Nielsen, DR Getts, DR Rhodes, Elizabeth A. Kaiser, F Geissmann, F Geissmann, F Geissmann, FK Swirski, H Saji, HP Gerber, Hui Zhang, Jeffrey W. Pollard, JH Im, Jinghang Zhang, Jiufeng Li, JM Carton, Liam R. Campion, Linda A. Snyder, MD Abramoff, P Stern, P Tsui, RT Palframan, T Ueno, T Valkovic, Takanori Kitamura, Y Huang   +32 more
core   +2 more sources

Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]

, 2014
Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia, Canale, Fernando Pablo, Gastman, B, Gruppi, Adriana, Mena, Hebe Agustina, Montes, Carolina Lucia, Negrotto, Soledad, Ramello, María Cecilia, Tosello Boari, Jimena   +8 more
core   +5 more sources

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]

, 2012
Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Weidenbusch, Marc, Anders, Hans-Joachim
core   +1 more source

Identification and manipulation of tumor associated macrophages in human cancers [PDF]

, 2011
Evading immune destruction and tumor promoting inflammation are important hallmarks in the development of cancer. Macrophages are present in most human tumors and are often associated with bad prognosis.
A Algars, A Corthay, A Mantovani, A Mantovani, A Mantovani, A Puig-Kroger, A Rigo, A Takahashi, A Terlou, A Tzankov, AM Figel, B Caillou, BM Burt, BZ Qian, C Bailey, C Lonnroth, C Murdoch, C Porta, C Steidl, C van Kooten, CH Lee, CJ Melief, CM Ohri, CM Ohri, D Azambuja, D Duluc, D Hanahan, D Kabelitz, D Nagorsen, D Niino, D Pilling, D Wang, DG DeNardo, DG DeNardo, DI Gabrilovich, DM Kuang, DM Kuang, DM Mosser, E Choy, E Schmitt, E Zeni, EM Verdegaal, ES Jordanova, F Avila-Moreno, F Pages, F Porcheray, FA Verreck, FO Martinez, FO Martinez, GL Beatty, H Dalwadi, H Hasita, H Kurahara, H Roca, H Takayama, H Van Gorp, H Yu, HJ Zijlmans, I Espinosa, I Kryczek, I Kryczek, I Shabo, IH Bronkhorst, J Chen, J Coward, J Forssell, J Gadiot, J Ma, J Pander, J Zhang, JA Webster, JC Kang, JR Brown, JS Pettersen, K Kawamura, K Movahedi, L Apetoh, L Bingle, L Sanchez-Martin, LS Hammes, M Herfs, M Heusinkveld, M Ryder, M van Dongen, MB Maniecki, MD Martin, MH McLean, MJ Campbell, MJ Edelman, MJ Welters, MM Tiemessen, Moniek Heusinkveld, N Nonomura, N Obermajer, NN Hunder, PJ de Vos van Steenwijk, PJ Murray, R Bos, R Karim, RB Mailliard, RD Stout, RD Stout, RM Steinman, RS Freedman, S Banerjee, S Gordon, S Osinsky, S Wirths, SJ Piersma, Sjoerd H van der Burg, SK Biswas, T Krausgruber, T Kreider, T Lawrence, TJ Curiel, TO Jensen, W Xu, X Yang, Y Komohara, Y Nakanishi, YS Shieh   +120 more
core   +3 more sources

Notch Signaling in Macrophages in the Context of Cancer Immunity

Frontiers in Immunology, 2018
Macrophages play both tumor-suppressing and tumor-promoting roles depending on the microenvironment. Tumor-associated macrophages (TAMs) are often associated with poor prognosis in most, but not all cancer.
Tanapat Palaga, Tanapat Palaga, Wipawee Wongchana, Wipawee Wongchana, Patipark Kueanjinda, Patipark Kueanjinda   +5 more
doaj   +1 more source

Immunotherapy Targeting Tumor-Associated Macrophages

Frontiers in Medicine, 2020
Macrophages are phagocytic cells that play a broad role in maintaining body homeostasis and defense against foreign pathogens; whereas tumor-associated macrophages (TAMs) support tumor growth and metastasis by promoting cancer cell proliferation and ...
Yafei Liu, Rongsi Wang
doaj   +1 more source

Tumor-Associated Macrophages Affect the Tumor Microenvironment and Radioresistance via the Upregulation of CXCL6/CXCR2 in Hepatocellular Carcinoma

Biomedicines, 2023
Background: Hepatocellular carcinoma is the sixth most diagnosed malignancy and the fourth most common cause of cancer-related mortality globally. Despite progress in the treatment of liver cancer, nonsurgical treatments remain unsatisfactory, and only ...
Hsin-Lun Lee, Yi-Chieh Tsai, Narpati Wesa Pikatan, Chi-Tai Yeh, Vijesh Kumar Yadav, Ming-Yao Chen, Jo-Ting Tsai   +6 more
doaj   +1 more source

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]

, 2017
Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo, Andrey Loboda, Ashani T. Weeraratna, Ayumi Hashimoto, Brian Nam, Butowski, Carus, Challacombe, Chao, Charles Mulligan, Chunsheng Zhang, Condamine, Conway, Coussens, David W. Speicher, DeNardo, Dmitry I. Gabrilovich, Douglas Marvel, Ellen Puré, Fang Wang, Fearon, Feig, Finke, Fred Denstman, Gabrilovich, Gabrilovich, Gascard, Genovese, Gentles, Greenberg, Grivennikov, Guleria, Huang, Kato, Kumar, Ladanyi, Laxminarasimha Donthireddy, Lin, Linda A. Snyder, Lo, Lokeshwar, Lucas, Lucia R. Languino, MacDonald, Manuel A. Sepulveda, Mao, Marlee A. Goins, Messmer, Meyer, Mishra, Mitchem, Mok, Mok, Neil Hockstein, Newman, Noman, Obermajer, Ohno, Orimo, Peter Ordentlich, Pixley, Prashanthi Vonteddu, Pyonteck, Qin Liu, Ramachandran, Reeti Behera, Ries, Ries, Robert H. Vonderheide, Sasse, Sergio Lavilla-Alonso, Shanti Shakamuri, Sionov, Sluijter, Solito, Strachan, Szkandera, Talmadge, Tap, Thomas Condamine, Timothy Chao, Vetsika, Vinit Kumar, Wang, Weber, Xiaowei Xu, Xu, Yang, Zhang, Zhang, Zhu   +90 more
core   +2 more sources

A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation [PDF]

, 2018
Summary: Tumor-associated macrophages (TAMs) are critical for tumor metastasis. Two TAM subsets support cancer cell intravasation: migratory macrophages guide cancer cells toward blood vessels, where sessile perivascular macrophages assist their entry ...
Arwert, Esther, Condeelis, John S, Entenberg, David, Harney, Allison, Pollard, Jeffrey, Sahai, Erik, Wang, Yarong   +6 more
core   +2 more sources