Results 41 to 50 of about 9,505,976 (163)

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo [PDF]

, 2008
Resident macrophages are an integral component of many tissues and are important in homeostasis and repair. This study examines the contribution of resident tissue macrophages to bone physiology.
Chang, M. K., Kuliwaba, J., Fazzalari, N., Maylin, E., Raggatt, Liza-Jane, Kuliwaba, Julia S., Alexander, K., Hume, D., Schroder, Kate, Maylin, Erin R., Alexander, Kylie A., Maylin, E. R., Fazzalari, Nicola L., Raggatt, L. J., Ripoll, V., Alexander, K. A., Ripoll, V. M., Schroder, K., Ripoll, Vera M, Pettit, A., Raggatt, L., Pettit, Allison R., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A., Hume, David A., Pettit, A. R., Chang, M., Chang, Ming K.   +28 more
core   +1 more source

Targeting Tumor-Associated Macrophages for Imaging

Pharmaceutics, 2022
As an important component of the tumor immune microenvironment (TIME), tumor-associated macrophages (TAMs) occupy a significant niche in tumor margin aggregation and respond to changes in the TIME.
Jiahao Hu, Xiaoling Xu, Yongzhong Du
doaj   +1 more source

The double-edged sword role of tumor-associated macrophages: preventing or causing resistance to immunotherapy

Journal of Experimental & Clinical Cancer Research
Immunotherapy has transformed cancer treatment, yet only a subset of patients achieves durable responses. Although macrophages play a key role in modulating immune response and could be used to enhance immunotherapy response, accumulating evidence ...
Raheleh Roudi, Behnaz Beikzadeh, Babak Beikzadeh, Sima Kalantari, Navid Sobhani   +4 more
doaj   +1 more source

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients

BMC Cancer, 2012
Background Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages.
Medrek Catharina, Pontén Fredrik, Jirström Karin, Leandersson Karin   +3 more
doaj   +1 more source

CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion

Frontiers in Oncology, 2021
Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are among the most important and abundant players of the tumor microenvironment. CAFs as well as TAMs are known to play pivotal supportive roles in tumor growth and progression.
Gurcan Gunaydin
doaj   +1 more source

DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages

, 2020
Breast cancer (BC) is the second leading cause of cancer deaths among women. DEK is a known oncoprotein that is highly expressed in over 60% of breast cancers and is an independent marker of poor prognosis.
Lisa M. Privette Vinnedge, Mathieu Sertorio, Nicholas A. Pease, Miranda S. Shephard, Susan E. Waltz   +4 more
core   +1 more source

Therapeutic Targeting of Tumor-Associated Macrophages in Pancreatic Neuroendocrine Tumors. [PDF]

, 2018
Pancreatic neuroendocrine tumors (PNETs) represent a heterogeneous group of neuroendocrine neoplasms with varying biological behaviour and response to treatment. Although targeted therapies have been shown to improve the survival for patients at advanced
Sebastian Krug, Wiese, Dominik, Hüttelmaier, Stefan, Krug, Sebastian, Stefan Hüttelmaier, Johannes Haybaeck, Abbassi, Rami, Bence Sipos, Gress, Thomas M, Rami Abbassi, Haybaeck, Johannes, Aurel Perren, Perren, Aurel, Michl, Patrick, Sipos, Bence, Anja Rinke, Dominik Wiese, Thomas M. Gress, Peter Rexin, Rexin, Peter, Patrick Michl, Griesmann, Heidi, Heidi Griesmann, Blank, Annika, Rinke, Anja, Annika Blank   +25 more
core   +2 more sources

Tumor-Associated Macrophages Promote Metastasis of Oral Squamous Cell Carcinoma via CCL13 Regulated by Stress Granule

, 2022
M2 tumor-associated macrophages (TAMs) have been a well-established promoter of oral squamous cell carcinoma (OSCC) progression. However, the mechanisms of M2 TAMs promoting OSCC metastasis have not been elucidated clearly.
Shule Xie, Zhou, Bin, Min Fu, Xie, Shule, Zhu, Chuandong, Youyuan Wang, Guotao Wu, Zhixin Liu, Rui, Tao, Lianxi Mai, Liu, Zhixin, Mai, Lianxi, Bin Zhou, Tao Rui, Zhaoyu Lin, Wu, Guotao, Chuandong Zhu, Fu, Min, Lin, Zhaoyu, Wang, Youyuan   +19 more
core   +1 more source

Distinct Role of CD11b⁺Ly6G⁻Ly6C⁻ Myeloid-Derived Cells on the Progression of the Primary Tumor and Therapy-Associated Recurrent Brain Tumor

Cells, 2019
Myeloid-derived cells have been implicated as playing essential roles in cancer therapy, particularly in cancer immunotherapy. Most studies have focused on either CD11b+Ly6G+Ly6C+ granulocytic or polymorphonuclear myeloid-derived suppressor cells (G ...
Sheng-Yan Wu, Chi-Shiun Chiang
doaj   +1 more source

Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment

Marine Drugs, 2014
The prevailing paradigm states that cancer cells acquire multiple genetic mutations in oncogenes or tumor suppressor genes whose respective activation/up-regulation or loss of function serve to impart aberrant properties, such as hyperproliferation or ...
Carlos M. Galmarini, Maurizio D'Incalci, Paola Allavena   +2 more
doaj   +1 more source