Results 131 to 140 of about 9,505,641 (261)
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Advanced ScienceBackground Building upon our previous finding that tumor‐derived lactate activates DESMIN+ cancer‐associated fibroblasts (CAFs) to secrete interleukin‐8 (IL‐8), this study investigates the downstream IL‐8/C‐X‐C motif chemokine receptor 2 (CXCR2) axis in ...
Xuyu Gu +7 more
doaj +1 more source
Iterative Selection of DNA Nanostructures for Cellular Uptake
Advanced Materials, EarlyView.DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar +4 more
wiley +1 more source
Advanced Materials, EarlyView.Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song +8 more
wiley +1 more source
Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic
Advanced Robotics Research, EarlyView.Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang +5 more
wiley +1 more source
Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]
, 2013 Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core
Advanced SciencePolybromo 1 (PBRM1) ranks as the second most commonly mutated gene in clear cell renal cell carcinoma (ccRCC), while its role in immune escape remains elusive.
Wenjiao Xia +14 more
doaj +1 more source
Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy
Advanced Robotics Research, EarlyView.This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang +11 more
wiley +1 more source
Tumor-associated macrophages contribute to tumor hypoxia and glycolysis
, 2017 1
Bok, Seoyeon +4 more
core
The Role Of Tumor-Associated Macrophages In Human Skin Cancer [PDF]
, 2013 Inflammation has long been associated with tumorigenesis. Macrophages are cells of the innate immune system, whose density within tumors correlates with a worsening clinical prognosis in most types of tumors.
Cyrus, Nika
core