Results 101 to 110 of about 115,437 (312)
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan +4 morewiley +1 more sourceTen-year clinical outcome, toxicity and compliance of dose-dense sequential adjuvant administration of cyclophosphamide & epirubicin followed by docetaxel in patients with early breast cancer: A hellenic cooperative oncology group observational study (HE 10/10) with concurrent investigation of significance of tumor infiltrating lymphocytes
BreastBackground: Dose-dense sequential (dds) chemotherapy has changed the clinical outcome of patients with early breast cancer (BC). To investigate the impact of dose intensity (DI) in the adjuvant setting of BC, this observational trial (HE 10/10) was ...Foteinos-Ioannis Dimitrakopoulos, Anna Goussia, Georgia-Angeliki Koliou, Katerina Dadouli, Anna Batistatou, Helen P. Kourea, Mattheos Bobos, Petroula Arapantoni-Dadioti, Olympia Tzaida, Triantafyllia Koletsa, Sofia Chrisafi, Maria Sotiropoulou, Alexandra Papoudou-Bai, Irene Nicolaou, Antonia Charchanti, Davide Mauri, Gerasimos Aravantinos, Ioannis Binas, Eleni Res, Amanda Psyrri, Dimitrios Pectasides, Dimitrios Bafaloukos, Anna Koumarianou, Iliada Bompolaki, Georgios Rigakos, Charisios Karanikiotis, Angelos Koutras, Flora Zagouri, Helen Gogas, George Fountzilas +29 moredoaj +1 more sourceT Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy
Advanced Science, EarlyView.This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen +8 morewiley +1 more sourceDataSheet_1_Transcutaneous Vagal Nerve Stimulation Alone or in Combination With Radiotherapy Stimulates Lung Tumor Infiltrating Lymphocytes But Fails to Suppress Tumor Growth.docx
, 2021 Eva Reijmen (400077), Sven De Mey (11774321), Helena Van Damme (11774324), Kirsten De Ridder (11774327), Thierry Gevaert (3542396), Emmy De Blay (11774330), Luc Bouwens (179065), Christine Collen (3542387), Lore Decoster (2587618), Marijke De Couck (11774333), Damya Laoui (306504), Jacques De Grève (88630), Mark De Ridder (79855), Yori Gidron (11619524), Cleo Goyvaerts (9529571) +14 moreopenalex +2 more sourcesInteractions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy
Advanced Science, EarlyView.Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani +17 morewiley +1 more sourceAnalysis of Programmed Death-Ligand 1 Expression, Stromal Tumor-Infiltrating Lymphocytes, and Mismatch Repair Deficiency in Invasive Micropapillary Carcinoma of the Breast [PDF]
, 2019 S. Simonetti, Nuria Domínguez, Analía Elguezabal, Francesco Pepe, Mariantonia Nacchio, Floriana Conticelli, Umberto Malapelle, Giancarlo Troncone, L. Gil Sánchez, X. Guardia, Paolo Nucíforo, Luigi Insabato +11 moreopenalex +1 more sourceTailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy
Advanced Science, EarlyView.This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong +13 morewiley +1 more sourceFigure S7 from T Cells Expanded from PD-1<sup>+</sup> Peripheral Blood Lymphocytes Share More Clones with Paired Tumor-Infiltrating Lymphocytes
, 2023 Tiepeng Li, Lingdi Zhao, Yonghao Yang, Yao Wang, Yong Zhang, Jindong Guo, Guangyu Chen, Peng Qin, Benling Xu, Baozhen Ma, Fang Zhang, Yiman Shang, Qingjun Li, Kai Zhang, Dongfeng Yuan, Chaojie Feng, Yan Ma, Xiaogang Li, Zhichao Tian, Hongle Li, Shengdian Wang, Quanli Gao +21 moreopenalex +1 more source
