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Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?
Frontiers in Immunology, 2022 Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are recruited into the tumor site to fight against tumors. However, their small number and reduced activity limit their ability to overcome the tumor. Enhancement of
M. Kazemi +6 more
semanticscholar +1 more source
Spatial Characterization of Tumor-Infiltrating Lymphocytes and Breast Cancer Progression
Cancers, 2022 Simple Summary The assessment of tumor-infiltrating lymphocytes (TILs) is gaining acceptance as a robust biomarker to help predict prognosis and treatment response.
Danielle Fassler +11 more
semanticscholar +1 more source
CD8+ T-cell lymphocytes infiltration predict clinical outcomes in Wilms’ tumor
Tumor Biology, 2020 The abundance and location of CD8+ tumor-infiltrating lymphocytes demonstrate important facets of the anticancer immune response. CD8-expressing lymphocytes have been used in immunotherapy for multiple cancers.
Keykhosro Mardanpour +4 more
doaj +1 more source
Annals of Oncology, 2015 BACKGROUND The morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is gaining momentum as evidence strengthens for the clinical relevance of this immunological biomarker.
Roberto Salgado +32 more
semanticscholar +1 more source
Life, 2020 Immunotherapy is a highly promising approach for the treatment of gastric cancer, the third-leading cause of overall cancer death worldwide. In particular, tumor-infiltrating lymphocytes and peripheral blood mononuclear cells are believed to mediate host
Wei-Ming Chen +6 more
doaj +1 more source
T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation [PDF]
, 1992 Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading to tissue damage ...
Eisenburg, Josef +9 more
core +1 more source
Biomedicines, 2022 Oropharynx squamous cell carcinoma (OPSCC) is of special interest because human papilloma virus (HPV) and/or smoking cause this disease. Influxes of inflammatory cells into such tumors are known to vary with prognoses.
Hilde Haave +7 more
doaj +1 more source
Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]
, 2006 Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core +1 more source
The biologic importance of tumor‐infiltrating lymphocytes [PDF]
Journal of Cutaneous Pathology, 2010 Detailed pathologic analysis has delineated a close association between intratumoral CD 8+ cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the presence at tumor sites of negative immune regulatory elements, such as FoxP 3+ T cells (Tregs) and PD‐1/PD‐L1 co‐stimulatory molecules, is closely associated with inferior ...
F Stephen, Hodi, Glenn, Dranoff
openaire +2 more sources
Ukrainian Scientific Medical Youth Journal, 2019 The article summarizes data and presents own study about the value of tumor-infiltrating lymphocytes as a prognostic factor for breast cancer including triple negative breast cancer lacking estrogen and progesterone receptors and HER2\new amplification ...
Liubov Zakhartseva, Mariia Yanovytska
doaj +1 more source