Results 111 to 120 of about 141,925 (244)

MicroRoboScope: A Portable and Integrated Mechatronic Platform for Magnetic and Acoustic Microrobotic Experimentation

Advanced Robotics Research, EarlyView.
This work presents the MicroRoboScope, a highly integrated, compact, and portable microrobotic experimentation platform combining electromagnetic and acoustic actuation with real‐time visual feedback into a single, end‐to‐end device. The system enables closed‐loop control and tracking algorithm experimentation within an accessible and unified hardware ...
Max Sokolich, Yanda Yang, Subrahmanyam Cherukumilli, Fatma Ceren Kirmizitas, Sambeeta Das   +4 more
wiley   +1 more source

Tumor organoids as a revolutionary platform for advancing cancer nanomedicine

Molecular Cancer
Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models ...
Chenyu Wu, Jingyao Chen, Chuanyi Zhang, Jiecheng Ji, Yinhua Tan, Zhichang Liu, Qiang Wu, Xiuli Zheng, Kui Luo, Kai Xiao   +9 more
doaj   +1 more source

Multiscale vascularized tumor-on-a-chip via bioprinting for drug research

International Journal of Bioprinting
Current in vitro tumor models often fail to recapitulate the hierarchical vascular architecture and dynamic interactions of the tumor microenvironment (TME), limiting their utility in cancer research. In this study, we present a multiscale vascularized tumor model integrating coaxial bioprinting, inkjet printing, and fused deposition modeling (FDM) to ...
Jing Liu, Ying Zhao, Bihan Ren, Dingming Li, Tianma He, Haizhongshi Zhang, Zhenlei Zhang, Haochen Liu   +7 more
openaire   +1 more source

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

The ablation margin as a regenerative and immunosuppressive niche in hepatocellular carcinoma: multicellular remodeling and organoid-on-a-chip modeling

Frontiers in Bioengineering and Biotechnology
Thermal ablation is an important local treatment for hepatocellular carcinoma (HCC), yet post-ablation local tumor progression remains a major obstacle to durable disease control. Traditionally, recurrence has been attributed mainly to incomplete thermal
Tingyue Qiao, Yang Zha, Honghua Dai, Yue Chai, Li Weng   +4 more
doaj   +1 more source

3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-Chip. [PDF]

Adv Healthc Mater, 2023
Li W, Zhou Z, Zhou X, Khoo BL, Gunawan R, Chin YR, Zhang L, Yi C, Guan X, Yang M.   +9 more
europepmc   +1 more source

A Low‐Cost, Handheld Optical Stiffness Sensor for Minimally Invasive Surgery

Advanced Robotics Research, EarlyView.
A novel handheld stiffness sensor is presented for real‐time tissue stiffness characterization. By simultaneously sensing contact force and tissue deformation, the device enables accurate stiffness quantification without requiring precise manual control. This approach offers a promising solution for intraoperative tumor detection and minimally invasive
Qianyu Ma, Ruxiang Jiang, Kaspar Althoefer, Nicolas Herzig, Hareesh Godaba   +4 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip. [PDF]

Biosens Bioelectron, 2023
Zhou L, Liu L, Chang MA, Ma C, Chen W, Chen P.   +5 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source