Results 61 to 70 of about 26,025 (289)

Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy. [PDF]

PLoS ONE, 2015
Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as ...
Nazanin Ruppender, Sandy Larson, Bryce Lakely, Lori Kollath, Lisha Brown, Ilsa Coleman, Roger Coleman, Holly Nguyen, Peter S Nelson, Eva Corey, Linda A Snyder, Robert L Vessella, Colm Morrissey, Hung-Ming Lam   +13 more
doaj   +1 more source

A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors

Translational Oncology, 2022
The involvement of cancer stem cells (CSCs) in driving tumor dormancy and drug resistance is well established. Most therapeutic regimens however are ineffective in targeting these regenerative populations.
Rajkumar S. Kalra, Gaurav S. Soman, Pradeep B. Parab, Avinash M. Mali, Sagar S. Varankar, Rutika R. Naik, Swapnil C. Kamble, Jaspreet K. Dhanjal, Sharmila A. Bapat   +8 more
doaj   +1 more source

The clinical and prognostic use of circulating tumour cells in breast cancer [PDF]

, 2011
Adjuvant therapies such as endocrine or cytotoxic chemotherapy have been demonstrated to improve overall survival in early breast cancer patients.
Payne, Rachel, Payne, Rachel
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Proliferation Pattern of Pediatric Tumor-Derived Mesenchymal Stromal Cells and Role in Cancer Dormancy: A Perspective of Study for Surgical Strategy

Frontiers in Pediatrics, 2021
The explanation for cancer recurrence still remains to be fully elucidated. Moreover, tumor dormancy, which is a process whereby cells enter reversible G0 cell cycle arrest, appears to be a critical step in this phenomenon.
Gloria Pelizzo, Gloria Pelizzo, Federica Riva, Stefania Croce, Maria Antonietta Avanzini, Gloria Acquafredda, Annalisa de Silvestri, Emanuela Mazzon, Placido Bramanti, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti, Giuliano Mazzini, Valeria Calcaterra, Valeria Calcaterra   +13 more
doaj   +1 more source

Niche inheritance: a cooperative pathway to enhance cancer cell fitness though ecosystem engineering [PDF]

, 2014
Cancer cells can be described as an invasive species that is able to establish itself in a new environment. The concept of niche construction can be utilized to describe the process by which cancer cells terraform their environment, thereby engineering ...
Barar J, Elton CS, Faraji F, Fidler IJ, Folkman J, Gatenby RA, Healy M, Hutchinson GE, Odling‐Smee FJ, Odling‐Smee FJ, Paget S, Pienta KJ, Weiss L, Wey JS   +13 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The Role of Regulatory B Cell-Like Malignant Cells and Treg Cells in the Mouse Model of BCL1 Tumor Dormancy. [PDF]

PLoS ONE, 2016
Cancer dormancy is a clinical state in which residual tumor cells persist for long periods of time but do not cause detectable disease. In the mouse B cell lymphoma model (BCL1), dormancy can be induced and maintained by immunizing mice with a soluble ...
Andrew BitMansour, Laurentiu M Pop, Ellen S Vitetta   +2 more
doaj   +1 more source

Mathematical modeling of the metastatic process

, 2013
Mathematical modeling in cancer has been growing in popularity and impact since its inception in 1932. The first theoretical mathematical modeling in cancer research was focused on understanding tumor growth laws and has grown to include the competition ...
AJ Minn, ARA Anderson, CFJM Peeters, CL Chaffer, D Dingli, D Piez, F Michor, F Michor, FA Greco, French SW Disibio Guy, GM Saidel, H Enderling, H Enderling, H Enderling, H Haeno, J Scott, JG Scott, JL Xu, JP Thiery, JW Baish, JW Baish, K Iwata, L Hanin, L Norton, LA Liotta, LA Liotta, LA Liotta, LL Chen, M Retsky, ML Neal, MT Milano, MT Milano, MW Retsky, P Diaconis, P Gerlee, PD Bos, PK Newton, PK Newton, R Bartoszyński, R Demicheli, R Demicheli, R Demicheli, S Eikenberry, T Hillen, W Britta, Y Kim   +45 more
core   +1 more source

Metastasis dormancy in estrogen receptor-positive breast cancer. [PDF]

, 2013
About 20% to 40% of patients with breast cancer eventually develop recurrences in distant organs, which are often not detected until years to decades after the primary tumor diagnosis.
Giuliano M, Osborne CK, Schiff R, Trivedi MV, Zhang XH   +4 more
core   +1 more source