Results 91 to 100 of about 1,922,670 (308)

Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake

, 2021
A basic requirement of tumorigenesis is the development of a vascular network to support the metabolic requirements of tumor growth and metastasis.
Jack Lawler, Kathy Matuszewska, Duncan Petrik, Jim Petrik, Madison Pereira   +4 more
core   +1 more source

Cycling Hypoxia Induces a Specific Amplified Inflammatory Phenotype in Endothelial Cells and Enhances Tumor-Promoting Inflammation In Vivo

Neoplasia: An International Journal for Oncology Research, 2015
Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia.
Céline Tellier, Déborah Desmet, Laurenne Petit, Laure Finet, Carlos Graux, Martine Raes, Olivier Feron, Carine Michiels   +7 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Hypoxia as a Target for Combination with Transarterial Chemoembolization in Hepatocellular Carcinoma

Pharmaceuticals
Hypoxia is a hallmark of solid tumors, including hepatocellular carcinoma (HCC). Hypoxia has proven to be involved in multiple tumor biological processes and associated with malignant progression and resistance to therapy. Transarterial chemoembolization
Zizhuo Wang, Qing Li, Bin Liang
doaj   +1 more source

Overcoming tumor hypoxia

, 2023
Hypoxia – defined as a low level of oxygen – is a common characteristic of the majority of solid tumors and contributes to disease progression and resistance to conventional therapies. Overcoming tumor hypoxia is therefore a promising strategy to improve cancer treatment.
openaire   +2 more sources

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy

, 2019
A smart theranostic prodrug IMC-FDU-TZBC-NO2, releasing active drug on-demand based on hypoxia-activated and indomethacin-mediated, for solid tumor imaging and efficient therapy was designed.
Jiaxin Gao (165107), Shuxiang Wang (750591), Yumeng Yuan (7521347), Weiyan Lei (7521350), Xiaoran Peng (5748401), Shenghui Li (432673), Jinchao Zhang (1324296), Haitong Liu (5748398)   +7 more
core   +1 more source

Hypoxia-Activated Albumin-Binding Exatecan Prodrug for Cancer Therapy

, 2021
As an effective drug delivery strategy for traditional antitumor drugs, the stimulus-responsive albumin-based prodrugs are getting more and more attention. These prodrugs only release drugs in specific tumor microenvironments, which can prevent premature
Shulei Zhu (8821937), Ying Huang (53474), Pingxuan Shao (11888119), Zhiyang Cheng (11888116), Shulei Zhu, Lei Wang (6656), Ying Huang, Lei Wang, Zhiyang Cheng, Jiahui Yu, Wei Lu, Jiahui Yu (4184329), Wei Lu (3580), Pingxuan Shao   +13 more
core   +1 more source