Results 111 to 120 of about 1,922,670 (308)

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance

Journal of Hematology & Oncology
In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature of solid tumors and is strongly associated with poor prognosis in cancer patients.
Tongxuan Shang, Ziqi Jia, Jiayi Li, Heng Cao, Hengyi Xu, Lin Cong, Dongxu Ma, Xiang Wang, Jiaqi Liu   +8 more
doaj   +1 more source

Hypoxia-driven tumor immune escape: mechanisms and therapeutic opportunities

Frontiers in Immunology
Hypoxia is a common feature of solid tumors and a major driver of tumor immune escape. It arises from abnormal tumor vasculature and rapid tumor growth, leading to persistent or fluctuating oxygen deprivation within the tumor microenvironment.
Hongran Qin, Shuqiang Yang, Jiawei He, Meijia Zhao, Luqian Zhao, Jingjing Wang, Xiulin Jiang, Xiaowen Chen, Xin Xu   +8 more
doaj   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy

, 2017
Poor tumor penetration is a major challenge for the use of nanoparticles in anticancer therapy. Moreover, the inability to reach hypoxic tumor cells that are distant from blood vessels results in inadequate exposure to antitumor therapeutics and ...
Ying Xie (50016), David Oupický (1319778), Yazhe Wang (1742299), Jing Li (10611), Yuri Sheinin (3719248), Jianping Zhou (348873), Zheng-Hong Peng (1591861)   +6 more
core   +1 more source

Multifunctional and endogenous stimuli-responsive vinblastine sulfate/manganese dioxide nanodrugs for enhancing chemotherapeutic efficacy against hypoxic tumors

Materials Today Bio
Several solid tumors contain large hypoxic regions, diminishing drug responses and resulting in limited therapeutic outcomes. Vinblastine sulfate (VBL) targets the tubulin molecule, causing microtubule depolymerization and inducing mitotic arrest ...
Yong Geun Lim, Yeji Chang, Seon-Ju Park, Kyoung-Dong Kim, Kyeongsoon Park   +4 more
doaj   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens [PDF]

, 2010
Background: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Peschel, Andreas, Edelmann, Markus, Schäfer, Andrea, Werth Nadine, Andreas Peschel, Volkhard A. J. Kempf, Edelmann Markus, Yazdi Amir S., Becker, Karsten, Rosenberger, Christian, Nadine Werth, Amir S Yazdi, Volkhard A J Kempf, Bernhardt Wanja, Kempf, Volkhard A. J., Amr, Amro, Rosenberger Christian, Amr Amro, Werth, Nadine, Andrea Schäfer, Peschel Andreas, von Eiff Christof, Christiane Beerlage, Kempf Volkhard A. J., Eiff, Christof von, Amro Amr, Becker Karsten, Beerlage, Christiane, Christof von Eiff, Wanja Bernhardt, Yazdi, Amir Sadegh, Bernhardt, Wanja, Christian Rosenberger, Karsten Becker, Schäfer Andrea, Beerlage Christiane, Amir S. Yazdi, Markus Edelmann, von Eiff, Christof, Yazdi, Amir S.   +39 more
core   +2 more sources