Results 101 to 110 of about 1,922,670 (308)
Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley +1 more source
Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
, 2015 Sergey V Karakashev, Mauricio J Reginato Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer.
Reginato MJ, Karakashev SV
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Current Understanding of Hypoxia in Glioblastoma Multiforme and Its Response to Immunotherapy
, 2022 Hypoxia is a hallmark of glioblastoma multiforme (GBM), the most aggressive cancer of the central nervous system, and is associated with multiple aspects of tumor pathogenesis.
Heung Kyu Lee, Jang Hyun Park
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Hypoxia-active nanoparticles used in tumor theranostic
International Journal of Nanomedicine, 2019 Yaqin Wang,1,2,* Wenting Shang,2,* Meng Niu,1 Jie Tian,2,3 Ke Xu11Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China; 2Chinese Academy of Sciences Key Laboratory ...
Wang Y, Shang W, Niu M, Tian J, Xu K
doaj
PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Polycomb group factor 1 (PCGF1) and coiled‐coil domain‐containing protein 34 (CCDC34) have been implicated in tumorigenesis in multiple malignancies. However, their biological functions and prognostic significance in glioma remain poorly defined.
Yuanbing Chen +7 more
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Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity [PDF]
, 2019 peer reviewedCancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including colorectal carcinoma.
NICOT, Nathalie +11 more
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Advanced Functional Materials, EarlyView.UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li +10 more
wiley +1 more source
, 2021 Cancer response to chemotherapy is regulated not only by intrinsic sensitivity of cancer cells but also by tumor microenvironment. Tumor hypoxia, a condition of low oxygen level in solid tumors, is known to increase the resistance of cancer cells to ...
Fong-Yu Cheng +5 more
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Advanced Healthcare Materials, EarlyView.This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar +2 more
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Hypobaric hypoxia exposure regulates tissue distribution of nanomedicine for enhanced cancer therapy
Cancer NanotechnologyBackground Effective drug delivery of nanomedicines to targeted sites remains challenging. Given that hypobaric hypoxia and hyperbaric oxygen exposure can significantly change pharmacokinetics of drugs, it is interesting to determine whether they can ...
Ye Tao, Zhongping Chen
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