Results 271 to 280 of about 368,090 (311)
Immune Cells Within the Tumor Microenvironment
, 2013 A plethora of intrinsic and extrinsic factors, including communication between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells, vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the tumor microenvironment.
ZOLLO, MASSIMO, SPANO, DANIELA
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Co-dependencies in the tumor immune microenvironment
Oncogene, 2022Activated oncogenes and disrupted tumor suppressor genes (TSGs) not only endow aspiring cancer cells with new biological capabilities but also influence the composition and function of host cells in the tumor microenvironment (TME). These non-cancer host cells can in turn provide cancer cells with growth support and protection from the anti-tumor ...
Peiwen Chen, Prasenjit Dey
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The tumor immune-microenvironment in gastric cancer
Tumori Journal, 2022Aims and Background: The tumor microenvironment significantly influences malignant behavior and progression. Many components are involved in the tumor microenvironment, including extracellular matrix, stromal cells, immune and inflammatory cells, as well as cytokines that promote tumor development with complex ...
Fujin Fang +5 more
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Tumor Microenvironment and the Immune Response
Surgical Oncology Clinics of North America, 2007Without clinical information, accurate follow-up, high-quality sample collection, and preservation, scientific conclusions are only based on theoretical assumptions that are unlikely to lead to clinical breakthroughs. In this article we discuss our understanding of the relationship between cancer cells and the host immune response.
S. Selleri +4 more
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Adaptive Immunity and the Tumor Microenvironment
2020The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
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Tumor Microenvironment and Immune Escape
Surgical Oncology Clinics of North America, 2007This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
Soldano, Ferrone, Theresa L, Whiteside
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Immune Suppression in the Tumor Microenvironment
Journal of Immunotherapy, 2006The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski +2 more
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The tumor immune microenvironment in peritoneal carcinomatosis
2022One in four patients with colorectal cancer, 40% of gastric cancer patients, and 60% of ovarian cancer patients will develop peritoneal metastases (PM) in the course of their disease. The outcome of patients with widespread PM remains poor with currently available treatments.
Jesse, Demuytere +4 more
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Cytokines and Immune Response in the Tumor Microenvironment
Journal of Immunotherapy, 2001SUMMARY: Over the last few decades a wealth of evidence has been gathered on the potential role that the immune system (IS) can play in the fight against cancer. Together with cell surface adhesion molecules, cytokines (CKs) mediate the activities of IS cells.
MOCELLIN, SIMONE, WANG E, MARINCOLA FM
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Targeting of the tumor immune microenvironment by metformin
Journal of Cell Communication and Signaling, 2021Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4 + and CD8 + T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor microenvironment (TME). In contrast to these cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and ...
Zihong Wu, Caidie Zhang, Masoud Najafi
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