Results 271 to 280 of about 469,202 (307)

Immune Suppression in the Tumor Microenvironment

Journal of Immunotherapy, 2006
The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski, Yuru, Meng, Helena, Harlin   +2 more
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Immune Cells Within the Tumor Microenvironment

2013
A plethora of intrinsic and extrinsic factors, including communication between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells, vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the tumor microenvironment.
ZOLLO, MASSIMO, SPANO, DANIELA
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Spatial landscape of the tumor immune microenvironment

Trends in Cancer, 2023
Two recent studies published in Nature by Karimi et al. and Sorin et al. applied multiplexed imaging mass cytometry (IMC) to characterize the single-cell tumor immune landscapes covering millions of cells in brain tumors and lung adenocarcinomas (LUAD).
Yamei, Chen, Yuan, Liu, Leng, Han
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Exosomes Function in Tumor Immune Microenvironment

2018
Immune cells and mesenchymal stem/stromal cells are the major cellular components in tumor microenvironment that actively migrate to tumor sites by sensing "signals" released from tumor cells. Together with other stromal cells, they form the soil for malignant cell progression.
Yin, Huang, Keli, Liu, Qing, Li, Yikun, Yao, Ying, Wang   +4 more
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Innate immune cells in the tumor microenvironment

Cancer Cell, 2021
The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies.
Li, Ming O, Wolf, Natalie, Raulet, David H, Akkari, Leila, Pittet, Mikaël, Rodriguez, Paulo C, Kaplan, Rosandra N, Munitz, Ariel, Zhang, Zemin, Cheng, Sijin, Bhardwaj, Nina   +10 more
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Immune Cell Metabolism in Tumor Microenvironment

2017
Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME, which intimately links immune cell
Yongsheng, Li, Yisong Y, Wan, Bo, Zhu
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CCL21 Programs Immune Activity in Tumor Microenvironment

2020
CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated immune activity in the TME.
Sherven, Sharma, Pournima, Kadam, Steven, Dubinett   +2 more
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Multifunctional Liposomes Remodeling Tumor Immune Microenvironment for Tumor Chemoimmunotherapy

Small Methods, 2023
AbstractIn the treatment of solid tumors, the complex barriers composed of cancer‐associated fibroblasts (CAFs) prevent drug delivery and T cells infiltration into tumor tissues. Although nanocarriers hold great prospects in drug delivery, fibrosis causes the biological barrier and immunosuppressive tumor microenvironment (ITM) that impairs the anti ...
Xinyang Li, Yang Luo, Zhengjie Huang, Yi Wang, Jian Wu, Shaobing Zhou   +5 more
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Immune resistance orchestrated by the tumor microenvironment

Immunological Reviews, 2006
Summary:  It is now little disputed that most if not all cancer cells express antigens that can be recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti‐tumor immunity is why such antigen‐expressing tumors are not spontaneously eliminated by the immune system.
Thomas F, Gajewski, Yuru, Meng, Christian, Blank, Ian, Brown, Aalok, Kacha, Justin, Kline, Helena, Harlin   +6 more
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The tumor immune microenvironment in peritoneal carcinomatosis

2022
One in four patients with colorectal cancer, 40% of gastric cancer patients, and 60% of ovarian cancer patients will develop peritoneal metastases (PM) in the course of their disease. The outcome of patients with widespread PM remains poor with currently available treatments.
Jesse, Demuytere, Sam, Ernst, Judith, van Ovost, Sarah, Cosyns, Wim, Ceelen   +4 more
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