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Impact of oral anaerobic bacteria on the tumor immune microenvironment and prognosis of oral cancer. [PDF]
J Transl MedKashima K +6 more
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The Tumor Microenvironment Reprograms Immune Cells
Cellular Reprogramming, 2022Tumor tissue comprises a highly complex network of diverse cell types. The tumor microenvironment (TME) can be mainly subdivided into cancer cells and stromal cell compartments, the latter include different types of immune cells, fibroblasts, endothelial cells, and pericytes.
Handi Cao +3 more
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Tumor Microenvironment and Immune Escape
Surgical Oncology Clinics of North America, 2007This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
Soldano, Ferrone, Theresa L, Whiteside
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Tumor Microenvironment and the Immune Response
Surgical Oncology Clinics of North America, 2007Without clinical information, accurate follow-up, high-quality sample collection, and preservation, scientific conclusions are only based on theoretical assumptions that are unlikely to lead to clinical breakthroughs. In this article we discuss our understanding of the relationship between cancer cells and the host immune response.
S. Selleri +4 more
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Co-dependencies in the tumor immune microenvironment
Oncogene, 2022Activated oncogenes and disrupted tumor suppressor genes (TSGs) not only endow aspiring cancer cells with new biological capabilities but also influence the composition and function of host cells in the tumor microenvironment (TME). These non-cancer host cells can in turn provide cancer cells with growth support and protection from the anti-tumor ...
Peiwen Chen, Prasenjit Dey
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Immune checkpoints in the tumor microenvironment
Seminars in Cancer Biology, 2020Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses against specific antigens. ICs and their ligands are frequently upregulated in the tumor microenvironment (TME) of various malignancies, and they represent significant barriers for induction of ...
Salman M, Toor +3 more
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Adaptive Immunity and the Tumor Microenvironment
2020The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
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The tumor immune-microenvironment in gastric cancer
Tumori Journal, 2022Aims and Background: The tumor microenvironment significantly influences malignant behavior and progression. Many components are involved in the tumor microenvironment, including extracellular matrix, stromal cells, immune and inflammatory cells, as well as cytokines that promote tumor development with complex interactions through the exchange of ...
Fujin Fang +5 more
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