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Immune resistance orchestrated by the tumor microenvironment
Immunological Reviews, 2006Summary: It is now little disputed that most if not all cancer cells express antigens that can be recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti‐tumor immunity is why such antigen‐expressing tumors are not spontaneously eliminated by the immune system.
Thomas F, Gajewski +6 more
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Immune Cells Within the Tumor Microenvironment
2013A plethora of intrinsic and extrinsic factors, including communication between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells, vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the tumor microenvironment.
ZOLLO, MASSIMO, SPANO, DANIELA
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Immune Cell Metabolism in Tumor Microenvironment
2017Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME, which intimately links immune cell
Yongsheng, Li, Yisong Y, Wan, Bo, Zhu
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Modification of the tumor microenvironment to enhance immunity
Frontiers in Bioscience, 2007The growth and spread of cancer depends as much on the host response to tumor as on the biological characteristics of the tumor itself. This interaction is at its most intimate and dynamic within the tumor microenvironment. It is here that the battle is fought that leads to mutual evolution of tumor and host cell phenotypes.
Yu-Pei, Liao +2 more
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The Role of Immune Cells in the Tumor Microenvironment
2006Interactions between tumor infiltrating leukocytes and tumor cells have been of great interest because of the possibility that immune cells either interfere with tumor progression or actively promote tumor growth. The tumor microenvironment is shaped by cells entering it, and their functions reflect the local conditions. Successive changes occurring at
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Glutamine and the Tumor Immune Microenvironment
European Urology, 2019Izak, Faiena, Daiki, Ueno, Brian, Shuch
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Metabolic programming and immune suppression in the tumor microenvironment
Cancer Cell, 2023Jeffrey Rathmell, Emily Arner
exaly
ADAPTIVE IMMUNITY AND THE TUMOR IMMUNE MICROENVIRONMENT
2019The adaptive immune system is essential for production of anti-tumor immune responses, with the majority of current immunotherapeutics designed to modulate the interaction between adaptive immunity and tumor cells within the tumor-immune microenvironment.
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