Results 221 to 230 of about 354,584 (265)

Immune checkpoints in the tumor microenvironment

Seminars in Cancer Biology, 2020
Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses against specific antigens. ICs and their ligands are frequently upregulated in the tumor microenvironment (TME) of various malignancies, and they represent significant barriers for induction of ...
Varun Sasidharan Nair, Eyad Elkord, Julie Decock   +2 more
exaly   +3 more sources

Tumor Microenvironment and the Immune Response

Surgical Oncology Clinics of North America, 2007
Without clinical information, accurate follow-up, high-quality sample collection, and preservation, scientific conclusions are only based on theoretical assumptions that are unlikely to lead to clinical breakthroughs. In this article we discuss our understanding of the relationship between cancer cells and the host immune response.
S. Selleri, C. Rumio, M. Sabatino, F. M. Marincola, E. Wang   +4 more
openaire   +2 more sources

Adaptive Immunity and the Tumor Microenvironment

2020
The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
openaire   +2 more sources

Tumor Microenvironment and Immune Escape

Surgical Oncology Clinics of North America, 2007
This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
Soldano, Ferrone, Theresa L, Whiteside
openaire   +2 more sources

Targeting of the tumor immune microenvironment by metformin

Journal of Cell Communication and Signaling, 2021
Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4 + and CD8 + T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor microenvironment (TME). In contrast to these cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and ...
Zihong Wu, Caidie Zhang, Masoud Najafi
openaire   +2 more sources

Immune Suppression in the Tumor Microenvironment

Journal of Immunotherapy, 2006
The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski, Yuru, Meng, Helena, Harlin   +2 more
openaire   +2 more sources

Cytokines and Immune Response in the Tumor Microenvironment

Journal of Immunotherapy, 2001
SUMMARY: Over the last few decades a wealth of evidence has been gathered on the potential role that the immune system (IS) can play in the fight against cancer. Together with cell surface adhesion molecules, cytokines (CKs) mediate the activities of IS cells.
MOCELLIN, SIMONE, WANG E, MARINCOLA FM
openaire   +3 more sources

Spatial landscape of the tumor immune microenvironment

Trends in Cancer, 2023
Two recent studies published in Nature by Karimi et al. and Sorin et al. applied multiplexed imaging mass cytometry (IMC) to characterize the single-cell tumor immune landscapes covering millions of cells in brain tumors and lung adenocarcinomas (LUAD).
Yamei, Chen, Yuan, Liu, Leng, Han
openaire   +2 more sources

Immune resistance orchestrated by the tumor microenvironment

Immunological Reviews, 2006
Summary:  It is now little disputed that most if not all cancer cells express antigens that can be recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti‐tumor immunity is why such antigen‐expressing tumors are not spontaneously eliminated by the immune system.
Thomas F, Gajewski, Yuru, Meng, Christian, Blank, Ian, Brown, Aalok, Kacha, Justin, Kline, Helena, Harlin   +6 more
openaire   +2 more sources