Results 221 to 230 of about 332,900 (265)

Formononetin suppresses osteosarcoma by targeting MYO1B and remodeling the tumor immune microenvironment. [PDF]

APL Bioeng
Liu Y, Xiong L, Feng W, Xie T, Liang J, Yang M, Li S, Luo K, Li F, Tang S, Liu S, Huang Q, Liao S, Liu J, Cai Y, Wei Q, Tang H, Tang F.   +17 more
europepmc   +1 more source

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Immune checkpoints in the tumor microenvironment

Seminars in Cancer Biology, 2020
Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses against specific antigens. ICs and their ligands are frequently upregulated in the tumor microenvironment (TME) of various malignancies, and they represent significant barriers for induction of ...
Varun Sasidharan Nair, Eyad Elkord, Julie Decock   +2 more
exaly   +3 more sources

Co-dependencies in the tumor immune microenvironment

Oncogene, 2022
Activated oncogenes and disrupted tumor suppressor genes (TSGs) not only endow aspiring cancer cells with new biological capabilities but also influence the composition and function of host cells in the tumor microenvironment (TME). These non-cancer host cells can in turn provide cancer cells with growth support and protection from the anti-tumor ...
Peiwen Chen, Prasenjit Dey
openaire   +2 more sources

The tumor immune-microenvironment in gastric cancer

Tumori Journal, 2022
Aims and Background: The tumor microenvironment significantly influences malignant behavior and progression. Many components are involved in the tumor microenvironment, including extracellular matrix, stromal cells, immune and inflammatory cells, as well as cytokines that promote tumor development with complex ...
Fujin Fang, Tiantian Zhang, Qiong Li, Xiaowei Chen, Fei Jiang, Xiaobing Shen   +5 more
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Tumor Microenvironment and the Immune Response

Surgical Oncology Clinics of North America, 2007
Without clinical information, accurate follow-up, high-quality sample collection, and preservation, scientific conclusions are only based on theoretical assumptions that are unlikely to lead to clinical breakthroughs. In this article we discuss our understanding of the relationship between cancer cells and the host immune response.
S. Selleri, C. Rumio, M. Sabatino, F. M. Marincola, E. Wang   +4 more
openaire   +2 more sources

Tumor Microenvironment and Immune Escape

Surgical Oncology Clinics of North America, 2007
This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
Soldano, Ferrone, Theresa L, Whiteside
openaire   +2 more sources

Adaptive Immunity and the Tumor Microenvironment

2020
The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
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Immune Suppression in the Tumor Microenvironment

Journal of Immunotherapy, 2006
The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski, Yuru, Meng, Helena, Harlin   +2 more
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Cytokines and Immune Response in the Tumor Microenvironment

Journal of Immunotherapy, 2001
SUMMARY: Over the last few decades a wealth of evidence has been gathered on the potential role that the immune system (IS) can play in the fight against cancer. Together with cell surface adhesion molecules, cytokines (CKs) mediate the activities of IS cells.
MOCELLIN, SIMONE, WANG E, MARINCOLA FM
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The immune microenvironments of lung and intraocular tumors

Bulletin du Cancer, 2011
An increasing body of evidence underlines the prominent role of the immune microenvironment in cancer growth, invasion and metastasis. The local immune responses are specialized in the different organs. We will discuss the composition of the immune microenvironments and their role on tumor development in two cancers developing in opposite contexts: in ...
Catherine, Sautès-Fridman, Marie-Caroline, Dieu-Nosjean, Diane, Damotte, Sylvain, Fisson, Wolf-Herman, Fridman   +4 more
openaire   +2 more sources