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Co-dependencies in the tumor immune microenvironment
Oncogene, 2022Activated oncogenes and disrupted tumor suppressor genes (TSGs) not only endow aspiring cancer cells with new biological capabilities but also influence the composition and function of host cells in the tumor microenvironment (TME). These non-cancer host cells can in turn provide cancer cells with growth support and protection from the anti-tumor ...
Peiwen Chen, Prasenjit Dey
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Immune Priming of the Tumor Microenvironment by Radiation
Trends in Cancer, 2016Ionizing irradiation can induce a multitude of alterations within the tumor microenvironment. Unlike targeted therapies, radiation delivered to the tumor bed can prompt phenotypic changes in both normal stromal and cancer cells, leading to molecular and physiological alterations within the tumor microenvironment.
Wen, Jiang +4 more
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Immune-suppressive properties of the tumor microenvironment
Cancer Immunology, Immunotherapy, 2013Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework.
Jýrgen C. Becker +3 more
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The tumor immune-microenvironment in gastric cancer
Tumori Journal, 2022Aims and Background: The tumor microenvironment significantly influences malignant behavior and progression. Many components are involved in the tumor microenvironment, including extracellular matrix, stromal cells, immune and inflammatory cells, as well as cytokines that promote tumor development with complex ...
Fujin Fang +5 more
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Ferroptosis of immune cells in the tumor microenvironment
Trends in Pharmacological Sciences, 2023Ferroptosis is a distinct form of cell death driven by the accumulation of peroxidized lipids. Characterized by alterations in redox lipid metabolism, ferroptosis has been implicated in a variety of cellular processes, including cancer. Induction of ferroptosis is considered a novel way to kill tumor cells, especially cells resistant to radiation and ...
Rina Kim +3 more
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Innate immune cells in the tumor microenvironment
Cancer Cell, 2021The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies.
Li, Ming O +10 more
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The Tumor Microenvironment Reprograms Immune Cells
Cellular Reprogramming, 2022Tumor tissue comprises a highly complex network of diverse cell types. The tumor microenvironment (TME) can be mainly subdivided into cancer cells and stromal cell compartments, the latter include different types of immune cells, fibroblasts, endothelial cells, and pericytes.
Handi Cao +3 more
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The immune microenvironments of lung and intraocular tumors
Bulletin du Cancer, 2011An increasing body of evidence underlines the prominent role of the immune microenvironment in cancer growth, invasion and metastasis. The local immune responses are specialized in the different organs. We will discuss the composition of the immune microenvironments and their role on tumor development in two cancers developing in opposite contexts: in ...
Catherine, Sautès-Fridman +4 more
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The role of coagulome in the tumor immune microenvironment
Advanced Drug Delivery Reviews, 2023The rising incidence and persistent thrombosis in multiple cancers including those that are immunosuppressive highlight the need for understanding the tumor coagulome system and its role beyond hemostatic complications. Immunotherapy has shown significant benefits in solid organ tumors but has been disappointing in the treatment of hypercoagulable ...
Riajul, Wahab +4 more
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Exosomes Function in Tumor Immune Microenvironment
2018Immune cells and mesenchymal stem/stromal cells are the major cellular components in tumor microenvironment that actively migrate to tumor sites by sensing "signals" released from tumor cells. Together with other stromal cells, they form the soil for malignant cell progression.
Yin, Huang +4 more
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