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High-content CRISPR screening in tumor immunology [PDF]
Frontiers in Immunology, 2022 CRISPR screening is a powerful tool that links specific genetic alterations to corresponding phenotypes, thus allowing for high-throughput identification of novel gene functions.
Kassidy Jungles +2 more
exaly +5 more sources
Epigenetics of Dendritic Cells in Tumor Immunology [PDF]
Cancers, 2022 Simple Summary Dendritic cells (DCs) are an important type of immune cell present in the blood and tissues, capable of detecting potential threats and displaying them to lymphocytes in the lymph nodes, therefore initiating lymphocyte-mediated responses ...
Esteban Ballestar, Godoy-Tena Gérard
exaly +3 more sources
Duality of B Cell-CXCL13 Axis in Tumor Immunology [PDF]
Frontiers in Immunology, 2020 Tumor immunity is a rapidly evolving area of research consisting of many possible permutations of immune cell tumor interactions that are dependent upon cell type, tumor type, and stage in tumor progression.
Tyrone Porter, Xuemei Zhong
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Roles for the FCRL6 Immunoreceptor in Tumor Immunology [PDF]
Frontiers in Immunology, 2020 Members of the Fc receptor-like (FCRL1–6) gene family encode transmembrane glycoproteins that are preferentially expressed by B cells and generally repress responses via cytoplasmic tyrosine-based regulation.
Randall Davis
exaly +3 more sources
The Role of Autophagy in Tumor Immunology—Complex Mechanisms That May Be Explored Therapeutically [PDF]
Frontiers in Oncology, 2020 The tumor microenvironment (TME) is complex, and its composition and dynamics determine tumor fate. From tumor cells themselves, with their capacity for unlimited replication, migration, and invasion, to fibroblasts, endothelial cells, and immune cells ...
Patricia Savio de Araújo-Souza +2 more
exaly +3 more sources
Exosome‐mediated regulation of tumor immunology [PDF]
Cancer Science, 2018 Exosomes are representative extracellular vesicles (EV) derived from multivesicular endosomes (MVE) and have been described as new particles in the communication of neighborhood and/or distant cells by serving as vehicles for transfer between cells of ...
Hiroshi Shiku, Naohiro Seo
exaly +3 more sources
Lipid metabolism in tumor immunology and immunotherapy. [PDF]
Front Oncol, 2023 Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness.
Duong LK +8 more
europepmc +2 more sources
In ovo model in cancer research and tumor immunology. [PDF]
Front Immunol, 2022 Considering cancer not only as malignant cells on their own but as a complex disease in which tumor cells interact and communicate with their microenvironment has motivated the establishment of clinically relevant 3D models in past years.
Miebach L, Berner J, Bekeschus S.
europepmc +2 more sources
Engineered exosomes for studies in tumor immunology. [PDF]
Immunol Rev, 2022 Exosomes are a type of extracellular vesicle (EV) with diameters of 30–150 nm secreted by most of the cells into the extracellular spaces and can alter the microenvironment through cell‐to‐cell interactions by fusion with the plasma membrane and ...
Alptekin A +4 more
europepmc +2 more sources
Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy. [PDF]
Front Immunol, 2022 Lung cancer is the second most common and the most lethal malignancy worldwide. It is estimated that lung cancer in never smokers (LCINS) accounts for 10-25% of cases, and its incidence is increasing according to recent data, although the reasons remain ...
de Alencar VTL +4 more
europepmc +2 more sources