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Applications of Single-Cell Omics in Tumor Immunology. [PDF]
Front Immunol, 2021 The tumor microenvironment (TME) is an ecosystem that contains various cell types, including cancer cells, immune cells, stromal cells, and many others. In the TME, cancer cells aggressively proliferate, evolve, transmigrate to the circulation system and
Liu J +7 more
europepmc +4 more sources
High-content CRISPR screening in tumor immunology [PDF]
Frontiers in Immunology, 2022 CRISPR screening is a powerful tool that links specific genetic alterations to corresponding phenotypes, thus allowing for high-throughput identification of novel gene functions.
Erin A. Holcomb +16 more
doaj +3 more sources
Tumor-derived microparticles in tumor immunology and immunotherapy. [PDF]
Eur J Immunol, 2020 Microvesicles or microparticles, a type of cytoplasm membrane‐derived extracellular vesicles, can be released by cancer cells or normal cell types. Alteration of F‐actin cytoskeleton by various signals may lead to the cytoplasm membrane encapsulating ...
Ma J, Zhang H, Tang K, Huang B.
europepmc +4 more sources
The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy. [PDF]
Front Immunol, 2020 Circular RNAs (circRNAs) are covalently closed RNA molecules in eukaryotes with features of high stability, tissue-specific and cell-specific expression. According to their biogenesis, circRNAs are mainly classified into five types, i.e. exonic circRNAs (
Fang Z, Jiang C, Li S.
europepmc +4 more sources
Organoid Models of Tumor Immunology. [PDF]
Trends Immunol, 2020 Cellular interactions in the tumor microenvironment (TME) significantly govern cancer progression and drug response. The efficacy of clinical immunotherapies has fostered an exponential interest in the tumor immune microenvironment, which in turn has engendered a pressing need for robust experimental systems modeling patient-specific tumor-immune ...
Yuki K, Cheng N, Nakano M, Kuo CJ.
europepmc +6 more sources
From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. [PDF]
Front ImmunolThe emergence of immunotherapies has revolutionized cancer treatment by leveraging the immune system to target malignancies, offering new hope where traditional therapies often fall short.
Abreu MM, Chocron AF, Smadja DM.
europepmc +3 more sources
Lipid metabolism in tumor immunology and immunotherapy. [PDF]
Front Oncol, 2023 Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness.
Duong LK +8 more
europepmc +2 more sources
In ovo model in cancer research and tumor immunology. [PDF]
Front Immunol, 2022 Considering cancer not only as malignant cells on their own but as a complex disease in which tumor cells interact and communicate with their microenvironment has motivated the establishment of clinically relevant 3D models in past years.
Miebach L, Berner J, Bekeschus S.
europepmc +2 more sources
Epigenetics of Dendritic Cells in Tumor Immunology. [PDF]
Cancers (Basel), 2022 Simple Summary Dendritic cells (DCs) are an important type of immune cell present in the blood and tissues, capable of detecting potential threats and displaying them to lymphocytes in the lymph nodes, therefore initiating lymphocyte-mediated responses ...
Godoy-Tena G, Ballestar E.
europepmc +2 more sources
Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy. [PDF]
Front Immunol, 2022 Lung cancer is the second most common and the most lethal malignancy worldwide. It is estimated that lung cancer in never smokers (LCINS) accounts for 10-25% of cases, and its incidence is increasing according to recent data, although the reasons remain ...
de Alencar VTL +4 more
europepmc +2 more sources