Results 141 to 150 of about 1,495,319 (256)

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications. [PDF]

NPJ Precis Oncol
Hill CM, Nwagwu CD, Odukoya AO, Hsueh B, Wang AZ, Dunn GP.   +5 more
europepmc   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

Advanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie, Jiahe Liu, Xiangyu Zhao, Siying Yang, Han Sun, Bingqian Jia, Xiaohong Ren, Xintao Chen, Lixin Sun, Li Wu, Caifen Wang, Jiwen Zhang   +11 more
wiley   +1 more source

Diverse origin and nature of tumor-infiltrating lymphocytes: the infection hypothesis. [PDF]

J Immunother Cancer
Gomez-Manzano C, Shin DH, Alvarez-Breckenridge C, Gillard AG, Morad G, Puduvalli VK, Alonso MM, Lang FF, Fueyo J.   +8 more
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Correction: An integrated automated deep learning framework for annotating tumor-infiltrating lymphocytes in lung adenocarcinoma pathology. [PDF]

Front Bioinform
Frontiers Production Office.
europepmc   +2 more sources

Tumor infiltrating lymphocytes against solid tumors: current trends & perspectives. [PDF]

PeerJ
Liew ZM, Low YS, Oh KC, Lee QY, Tye GJ, Bayliss R, Mai CW, Teo MYM, In LLA.   +8 more
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Assessment of the presence and anti-tumor potential of tumor-infiltrating lymphocytes in patients with acute myeloid leukemia

, 2019
Liya Wei,1 Zhenkun Wang,2 Zhuo Zhang,1 Yinghua Li,1 Shengjin Fan,1 Yanqiu Zhao,1 Zhiyu Liu,2 Xiangmei Ye,2 Fan Zhang,2 Yingying Yu,2 Xiaolong Liu,2 Fenglin Cao,2 Jin Zhou1,21Department of Hematology, The First Affiliated Clinical Hospital of Harbin ...
Zhang F, Cao F, Ye X, Fan S, Zhao Y, Liu X, Li Y, Liu Z, Zhang Z, Wang Z, Wei L, Yu Y, Zhou J   +12 more
core  

Functional cytokine-based classification of tumor-infiltrating lymphocytes in melanoma. [PDF]

Sci Rep
Bida M, Hull R, Miya TV, Marutha T, Dlamini Z.   +4 more
europepmc   +1 more source