Results 201 to 210 of about 115,861 (261)

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Single-Cell Dissection of Tumor-Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma. [PDF]

Adv Sci (Weinh)
Zhang C, Xiao W, Shen H, Li F, Li T, Zhang W, Liu H, Gao Z, Wang H, Ren X, Chen K, Li X, Yang J.   +12 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Automated quantification of tumor-infiltrating lymphocytes by machine learning reveals prognostic and immunogenomic features in lung cancer. [PDF]

Sci Rep
Li A, Pang Y, Zhang H, Wu D, Lin L, He Z, Liang Z, Chen J, Li F.   +8 more
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Prognostic Impact of CD8+ and CD4+ Tumor-Infiltrating Lymphocytes and Perineural/Vascular Invasion in Laryngeal Squamous Cell Carcinoma. [PDF]

Iran J Pathol
Lotfi M, Majdi M, Tanzifi P, Yousefi T, Nazar E, Nozheh A.   +5 more
europepmc   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Prognostic Value of Tumor-Infiltrating Lymphocytes in Resected Pancreatic Ductal Adenocarcinoma: A Single-Center Retrospective Australian Study. [PDF]

Cureus
Siribaddana H, Jayaratne P, Gounden S, Whittaker D, Burge M, Tran K, Hoff JW, Tee CL, Chandrasegaram MD.   +8 more
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Tumor-infiltrating lymphocytes demonstrate potent anti-tumor efficacy and synergize with PD-1 blockade in bladder cancer. [PDF]

J Transl Med
Huang GK, Zhang XX, Huang LY, Un HC, Lin RX, Chen JX, Wang ZR, Long LL.   +7 more
europepmc   +1 more source