Results 71 to 80 of about 489,862 (290)

Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1? [PDF]

, 2016
ncreasing lines of evidence indicate that NKG2D, an activating receptor of natural killer (NK) and CD8(+) T cells, plays an important role in immune responses against HIV-1. Through its ability to recognize a diverse array of ligands (NKG2DLs) induced by
Cerboni, Cristina, Doria, Margherita, Giuliani, Rica, Vassena, Lia   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pitfalls of Current Diagnostic Criteria of Tumor Lysis Syndrome

Kidney & Blood Pressure Research
Background: Tumor lysis syndrome (TLS) is a well-recognized medical emergency in patients with cancer diagnosis. The diagnostic criteria of TLS have been revised many times since it was recognized, but still have many drawbacks that limit diagnosis ...
Naji Alhamid, Bana Sabbagh, Asmaa Alsarraj, Edgar Lerma, Tiffany Caza, Biruh Workeneh, Jacqueline Claudia Barrientos, Kenar D. Jhaveri   +7 more
doaj   +1 more source

Hyperuricemic Renal Failure in Nonhematologic Solid Tumors: A Case Report and Review of the Literature

Case Reports in Medicine, 2012
Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by massive tumor cell lysis. It is commonly associated with hematological cancers like leukemia and lymphoma and uncommonly with solid nonhematologic tumors as well. However, spontaneous
Neeraj Saini, Kyeong Pyo Lee, Smita Jha, Sanket Patel, Neelima Bonthu, Ankit Kansagra, Ashmeet Bhatia, Sandra E. Martinez, Jaymin Patel, Sarah Altamimi, Sara Ghotb   +10 more
doaj   +1 more source

Síndrome de lise tumoral: uma revisão abrangente da literatura Acute tumor lysis syndrome: a comprehensive review

Revista Brasileira de Terapia Intensiva, 2008
A síndrome de lise tumoral é caracterizada pela destruição maciça de células malignas e conseqüente liberação do seu conteúdo no espaço extracelular. Embora possa ocorrer de modo espontâneo, a síndrome de lise tumoral aparece em geral, logo após o início
Michael Darmon, Sandra Malak, Isabelle Guichard, Benoit Schlemmer   +3 more
doaj   +1 more source

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis [PDF]

, 2020
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor ...
Burgers, Peter M, Chang, Matthew, Cobb, Jennifer A, Ghisays, Fiorella, Hailemariam, Sarem, Hohl, Marcel, Kuryavyi, Vitaly, Mojumdar, Aditya, Patel, Dinshaw J, Petrini, John H. J., Sorenson, Kyle, Taylor, Barry S   +11 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Tumor Lysis Syndrome

New England Journal of Medicine
Adeyinka A, Kaur A, Bashir K.
europepmc   +4 more sources

Transient myeloproliferative disorder in a newborn with down syndrome treated with rasburicase for the risk of development of tumor lysis syndrome: A case report

Journal of Medical Case Reports, 2011
Introduction Transient myeloproliferative disorder is a hematologic abnormality characterized by an uncontrolled proliferation of myeloblasts in peripheral blood and bone marrow that primarily affects newborns and babies with Down syndrome.
Hatzistilianou Maria, Hatzipantelis Emmanuel, Papageorgiou Theodotis, Pana Zoe, Tragiannidis Athanasios, Athanassiadou Fani   +5 more
doaj   +1 more source

Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. [PDF]

, 2007
We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions ...
Au, T, Kirn, D, Korn, WM, Reid, TR, Sze, D, Thorne, S   +5 more
core