Results 91 to 100 of about 3,534,255 (422)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance N6-methylation of adenosine (m6A) RNA modification plays important roles in development and tumorigenesis. The functions and mechanisms of m6A demethylases during cancer immunotherapy is still unclear.
Na Li, Yuqi Kang, Ling-Zen Wang, S. Huff, Rachel Tang, Hui Hui, Kriti Agrawal, G. Gonzalez, Yinsheng Wang, S. Patel, T. Rana   +10 more
semanticscholar   +1 more source

Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells

Journal for ImmunoTherapy of Cancer
Background Oncolytic viruses (OVs) are an attractive way to increase immune infiltration into an otherwise cold tumor. While OVs are engineered to selectively infect tumor cells, there is evidence that they can infect other non-malignant cells in the ...
Greg M Delgoffe, Kristin DePeaux, William G Gunn, Dayana B Rivadeneira   +3 more
doaj   +1 more source

Emergent Properties of Tumor Microenvironment in a Real-life Model of Multicell Tumor Spheroids [PDF]

, 2010
Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has the ability to shed light on the internal workings and organization of tumors at a critical phase of their development.
arxiv   +1 more source

Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. [PDF]

, 2017
Tumors adapt to an unfavorable microenvironment by controlling the balance between cell proliferation and cell motility, but the regulators of this process are largely unknown.
Ashani T. Weeraratna, Caino, Chae, Chandran, Dario C. Altieri, Dayana B. Rivadeneira, Dmitry I. Gabrilovich, Dong, Eui Tae Kim, Gao, Hecht, Hwang, Jae Ho Seo, Kim, LeBleu, Lucia R. Languino, M. Cecilia Caino, Yuan Wang   +17 more
core   +2 more sources

Tumor Microenvironment in the Brain [PDF]

Cancers, 2012
In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression.
openaire   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Blood Vessel Tortuosity Selects against Evolution of Agressive Tumor Cells in Confined Tissue Environments: a Modeling Approach [PDF]

PLoS Computational Biology 2017, 13(7): e1005635, 2017
Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and leading to a heterogeneous cell population within tissues. In the competition for nutrients and growth space within the tumors the phenotype of each cell determines its success. Selection in this process is imposed by both the microenvironment (neighboring
arxiv   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Frontiers in Immunology, 2020
The success of cancer immunotherapy relies on the knowledge of the tumor microenvironment and the immune evasion mechanisms in which the tumor, stroma, and infiltrating immune cells function in a complex network.
A. Labani-Motlagh, Mehrnoush Ashja-Mahdavi, A. Loskog   +2 more
semanticscholar   +1 more source