Results 71 to 80 of about 3,561,070 (402)
The updated landscape of tumor microenvironment and drug repurposing
Signal Transduction and Targeted Therapy, 2020 Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies.
Ming-zhu Jin, Wei-Lin Jin
semanticscholar +1 more source
Cellular interactions in the tumor microenvironment: the role of secretome [PDF]
, 2019 Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro +6 more
core +1 more source
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Journal of Hematology & OncologyCancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds.
Qiang Lu +15 more
semanticscholar +1 more source
Cancer Biology & MedicineObjective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen +10 more
doaj +1 more source
Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy
Frontiers in Molecular Biosciences, 2020 Solid tumors are complex organ-like structures that consist not only of tumor cells but also of vasculature, extracellular matrix (ECM), stromal, and immune cells.
E. Henke, R. Nandigama, S. Ergün
semanticscholar +1 more source
Tumor Microenvironment and Metabolism [PDF]
International Journal of Molecular Sciences, 2017 The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...]
openaire +3 more sources
Fibrocytes in the Tumor Microenvironment [PDF]
, 2020 Tumors have long been compared to chronic wounds that do not heal, since they share many of the same molecular and cellular processes. In normal wounds, healing processes lead to restoration of cellular architecture, while in malignant tumors, these healing processes become dysregulated and contribute to growth and invasion of neoplastic cells into the
Richard H. Gomer +2 more
openaire +2 more sources
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
Molecular Cancer, 2019 Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance.
Xinming Jing +6 more
semanticscholar +1 more source
Molecular Cancer, 2020 The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration remain unknown. We comprehensively evaluated
Bo Zhang +5 more
semanticscholar +1 more source
Diversity of Dynamics and Morphologies of Invasive Solid Tumors
, 2012 Complex tumor-host interactions can significantly affect the growth dynamics and morphologies of progressing neoplasms. The growth of a confined solid tumor induces mechanical pressure and deformation of the surrounding microenvironment, which in turn ...
Jiao, Yang, Torquato, Sal
core +2 more sources