Results 71 to 80 of about 3,620,379 (402)
Frontiers in Pharmacology, 2021 The Syrian golden hamster (Mesocricetus auratus) has recently been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals ...
Voddu Suresh +9 more
doaj +1 more source
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Journal of Hematology & OncologyCancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds.
Qiang Lu +15 more
semanticscholar +1 more source
Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Advancement of science, 2021 The past decades have witnessed great progress in cancer immunotherapy, which has profoundly revolutionized oncology, whereas low patient response rates and potential immune‐related adverse events remain major clinical challenges.
Shao-jun Peng +3 more
semanticscholar +1 more source
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core +1 more source
Tumor Microenvironment and Metabolism [PDF]
International Journal of Molecular Sciences, 2017 The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...]
openaire +3 more sources
Fibrocytes in the Tumor Microenvironment [PDF]
, 2020 Tumors have long been compared to chronic wounds that do not heal, since they share many of the same molecular and cellular processes. In normal wounds, healing processes lead to restoration of cellular architecture, while in malignant tumors, these healing processes become dysregulated and contribute to growth and invasion of neoplastic cells into the
Richard H. Gomer +2 more
openaire +2 more sources
Identification of Circular RNAs Associated With Chemoresistance in Colorectal Cancer
Frontiers in Genetics, 2021 Chemoresistance is a major clinical obstacle for the treatment of colorectal cancer (CRC). Circular RNAs (circRNAs) are a new type of non-coding RNA that participated in the development of chemoresistance. However, the profiles and effects of circRNAs in
Fei Yao +8 more
doaj +1 more source
bioRxiv, 2020 Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows remarkable efficacy in a variety of cancer types. However, only a minority of patients respond to treatment due to the stochastic heterogeneity of tumor microenvironment ...
Dongqing Sun +15 more
semanticscholar +1 more source
Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]
, 2017 A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro +4 more
core +2 more sources
The updated landscape of tumor microenvironment and drug repurposing
Signal Transduction and Targeted Therapy, 2020 Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies.
Ming-zhu Jin, Wei-Lin Jin
semanticscholar +1 more source