Results 71 to 80 of about 3,534,255 (422)
Frontiers in Pharmacology, 2021 The Syrian golden hamster (Mesocricetus auratus) has recently been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals ...
Voddu Suresh +9 more
doaj +1 more source
A Novel Framework for Characterization of Tumor-Immune Spatial Relationships in Tumor Microenvironment [PDF]
arXiv, 2022 Understanding the impact of tumor biology on the composition of nearby cells often requires characterizing the impact of biologically distinct tumor regions. Biomarkers have been developed to label biologically distinct tumor regions, but challenges arise because of differences in the spatial extent and distribution of differentially labeled regions ...
arxiv
Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]
, 2017 The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert +3 more
core +2 more sources
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
Molecular Cancer, 2019 Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance.
Xinming Jing +6 more
semanticscholar +1 more source
Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Advancement of science, 2021 The past decades have witnessed great progress in cancer immunotherapy, which has profoundly revolutionized oncology, whereas low patient response rates and potential immune‐related adverse events remain major clinical challenges.
Shao-jun Peng +3 more
semanticscholar +1 more source
The role of Microenvironment in tumorigenesis. Focus on dendritic cells in human papillomavirus E6, E7-transformed keratinocytes [PDF]
, 2015 The inception of tumor microenvironment (TME), a complex and dynamic system constituted by different types of cells engaged by tumor and extracellular matrix surrounding cancer cells, is a way for them to elude the immune surveillance.
Accardi, Rosita +6 more
core +1 more source
Cancer Biology & MedicineObjective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen +10 more
doaj +1 more source
Identification of Circular RNAs Associated With Chemoresistance in Colorectal Cancer
Frontiers in Genetics, 2021 Chemoresistance is a major clinical obstacle for the treatment of colorectal cancer (CRC). Circular RNAs (circRNAs) are a new type of non-coding RNA that participated in the development of chemoresistance. However, the profiles and effects of circRNAs in
Fei Yao +8 more
doaj +1 more source
Targeting the tumor microenvironment in colorectal peritoneal metastases
, 2020 Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim +4 more
core +1 more source
Tumor Microenvironment and Metabolism [PDF]
International Journal of Molecular Sciences, 2017 The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...]
openaire +3 more sources