Results 81 to 90 of about 3,620,379 (402)

Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages

Theranostics, 2021
Macrophages phagocytize pathogens to initiate innate immunity and products from the tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated macrophage (TAM)-mediated immune responses results in immune suppression.
Degao Chen, Xiaomei Zhang, Zhongjun Li, B. Zhu   +3 more
semanticscholar   +1 more source

DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs [PDF]

, 2019
Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with ...
Barcus, Craig E, Bayer, Samantha V.H., Brenot, Audrey, Ernst, Melanie, Grither, Whitney R, Hwang, Priscilla Y, Longmore, Gregory D, Pathak, Amit, Pence, Patrick, Walter, Christopher   +9 more
core   +1 more source

The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one [PDF]

, 2018
In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice.
Botticelli, A., Marchetti, P., Nuti, M., Rughetti, A., Zizzari, I. G.   +4 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance

International Journal on Biological Sciences, 2022
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic failure.
Aiping Zhang, Kai Miao, Heng Sun, Chuxia Deng   +3 more
semanticscholar   +1 more source

Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer [PDF]

, 2016
The aim of the present study was to compare the clinical utility of two measures of the inflammatory cell infiltrate - a H&E-based assessment of the generalised inflammatory cell infiltrate (the Klintrup-Mäkinen (KM) grade), and an ...
Edwards, J., Horgan, P. G., McMillan, D. C., Park, J. H., Roxburgh, Campbell S.D.   +4 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

IRE1α‐XBP1s axis regulates SREBP1‐dependent MRP1 expression to promote chemoresistance in non‐small cell lung cancer cells

Thoracic Cancer
Background Inositol‐requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)‐resident transmembrane protein that senses ER stress and mediates an essential arm of the unfolded protein response (UPR).
Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu   +9 more
doaj   +1 more source

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Molecular Cancer, 2019
Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance.
Xinming Jing, Fengming Yang, C. Shao, Ke Wei, M. Xie, H. Shen, Y. Shu   +6 more
semanticscholar   +1 more source

Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy

Frontiers in Molecular Biosciences, 2020
Solid tumors are complex organ-like structures that consist not only of tumor cells but also of vasculature, extracellular matrix (ECM), stromal, and immune cells.
E. Henke, R. Nandigama, S. Ergün
semanticscholar   +1 more source