Results 71 to 80 of about 2,631,955 (205)

Mutation Burden Predicts Anti–PD-1 Response

, 2018
A new study finds that objective response rates to anti–PD-1 therapies correlate with tumor mutation burden for most of the 27 cancer types studied. Objective response rates were higher than expected for Merkel cell carcinoma and renal cell carcinoma ...

core   +1 more source

Tumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpoint

Journal of Translational Medicine, 2023
Background Tumor cell density is a basic pathological feature of solid tumors. Chemotherapy, radiotherapy, and targeted therapy reduce tumor cell density, whereas unrestricted tumor cell proliferation promotes this feature.
Mengchao Yan, Jia Yao, Yan Lin, Jun Yan, Ye Xie, Zongli Fu, Yongqiang Zhou, Jiayun Wei, Xun Li   +8 more
doaj   +1 more source

Image1_USH2A Mutation is Associated With Tumor Mutation Burden and Antitumor Immunity in Patients With Colon Adenocarcinoma.tif

, 2021
Colon adenocarcinoma (COAD) is one of the diseases with the highest morbidity and mortality in the world. At present, immunotherapy has become a valuable method for the treatment of COAD.
Xuxu Liu (11130591), Biao Ma (260101), Dongbo Xue (22386), Long Li (6555), Yuanyuan Sun (505629), Wenchao Yao (8545611), Yang Yang (45629)   +6 more
core   +1 more source

Multi-omics analysis reveals prognostic value of tumor mutation burden in hepatocellular carcinoma

Cancer Cell International, 2021
Background Hepatocellular carcinoma (HCC) was the sixth common malignancies characteristic with highly aggressive in the world. It was well established that tumor mutation burden (TMB) act as indicator of immunotherapeutic responsiveness in various ...
Qianhui Xu, Hao Xu, Rongshan Deng, Zijie Wang, Nanjun Li, Zhixuan Qi, Jiaxin Zhao, Wen Huang   +7 more
doaj   +1 more source

Image3_USH2A Mutation is Associated With Tumor Mutation Burden and Antitumor Immunity in Patients With Colon Adenocarcinoma.tif

, 2021
Colon adenocarcinoma (COAD) is one of the diseases with the highest morbidity and mortality in the world. At present, immunotherapy has become a valuable method for the treatment of COAD.
Xuxu Liu (11130591), Biao Ma (260101), Dongbo Xue (22386), Long Li (6555), Yuanyuan Sun (505629), Wenchao Yao (8545611), Yang Yang (45629)   +6 more
core   +1 more source

MUC16 promotes endometrial cancer progression and modulates sensitivity to lapatinib through the ESR1/PI3K/AKT axis

Translational Oncology
Purpose: Endometrial cancer is one of the most common gynecological malignancies, and advanced disease remains associated with poor clinical outcomes.
Yan Yu, Shuqing Lv, Guanlong Li, Lingna Sun, Shan Su   +4 more
doaj   +1 more source

Correlate tumor mutation burden with immune signatures in human cancers

BMC Immunology, 2019
Background Tumor mutation burden (TMB) has been associated with cancer immunotherapeutic response and cancer prognosis. Although many explorations have revealed that high TMB may yield many neoantigens to incite antitumor immune response, a systematic ...
Xiaosheng Wang, Mengyuan Li
doaj   +1 more source

Image2_USH2A Mutation is Associated With Tumor Mutation Burden and Antitumor Immunity in Patients With Colon Adenocarcinoma.tif

, 2021
Colon adenocarcinoma (COAD) is one of the diseases with the highest morbidity and mortality in the world. At present, immunotherapy has become a valuable method for the treatment of COAD.
Xuxu Liu (11130591), Biao Ma (260101), Dongbo Xue (22386), Long Li (6555), Yuanyuan Sun (505629), Wenchao Yao (8545611), Yang Yang (45629)   +6 more
core   +1 more source

Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration.

PLoS Computational Biology, 2019
The somatic co-evolution of tumors and the cellular immune responses that combat them drives the diversity of immune-tumor interactions. This includes tumor mutations that generate neo-antigenic epitopes that elicit cytotoxic T-cell activity and ...
Boyang Zhao, Justin R Pritchard
doaj   +1 more source

High Tumor Mutational Burden in Hepatocellular Carcinoma

Cureus
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the leading causes of cancer-related deaths worldwide. Tumor mutational burden (TMB) in a cancer specimen represents the number of mutations within a pre-determined length of genetic material. This value is increasingly investigated as it may correlate with both prognosis
Engle, Joshua A, Dibb, James T, Jakob, John A   +2 more
openaire   +2 more sources