Results 1 to 10 of about 4,566 (176)

DNMT3B Promotes the Progression of Pheochromocytoma by Mediating the Hypermethylation of LRP1B Promoter [PDF]

Epigenetics and Chromatin
Background Pheochromocytoma (Pheo) represents a potential metastatic neuroendocrine tumor. As a tumor suppressor gene, LRP1B is involved in the regulation of tumor progression.
Min Sun, Yanrong Ma, Jing Wan, Bingli Zheng, Zhenfeng Shi, Jiuzhi Li   +5 more
exaly   +6 more sources

Molecular Characteristics and Cancer Immunity of LRP1B and Its Relationship With the Hedgehog Signaling Pathway in Colorectal Cancer [PDF]

Frontiers in Immunology
BackgroundColorectal cancer (CRC) is a malignant tumor of the digestive tract that significantly impacts human health. LDL receptor-related protein 1B (LRP1B) may play a crucial role in tumorigenesis and disease progression.MethodsWe performed a ...
Xingyu Zhu
exaly   +8 more sources

LRP1B: A Giant Lost in Cancer Translation [PDF]

Pharmaceuticals, 2021
Low-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR protein family, which includes several structurally homologous cell surface receptors with a wide range of biological functions from cargo transport to cell ...
Paula Soares, Catarina Príncipe, Hugo Prazeres   +2 more
exaly   +8 more sources

LRP1B Suppresses Immunotherapy Efficacy in Lung Adenocarcinoma by Preventing Ferroptosis [PDF]

Cancer Medicine
Background Immune biomarkers for non‐small‐cell lung cancer (NSCLC) are programmed death ligand 1 (PD‐L1) and tumor mutational burden (TMB). However, they cannot accurately predict the effectiveness of immunotherapy.
Zi‐Hao Ke, Ying Chen, Tao Yu, Qi Zhang, Yan Xiang, Kai‐Hua Lu   +5 more
doaj   +4 more sources

Comprehensive genetic variant analysis reveals combination of KRAS and LRP1B as a predictive biomarker of response to immunotherapy in patients with non-small cell lung cancer [PDF]

Journal of Experimental & Clinical Cancer Research
Background In non-small cell lung cancer (NSCLC), the rapid advancement of predictive genetic testing of tumors by identifying specific pathogenic driver variants has significantly improved treatment guidance. However, immune checkpoint blockade (ICB) is
Ella A. Eklund, Johanna Svensson, Louise Stauber Näslund, Maria Yhr, Sama I. Sayin, Clotilde Wiel, Levent M. Akyürek, Per Torstensson, Volkan I. Sayin, Andreas Hallqvist, Sukanya Raghavan, Anna Rohlin   +11 more
doaj   +3 more sources

Correlation analysis between plasma circulating tumour deoxyribonucleic acid variations and survival in patients with hepatocellular carcinoma [PDF]

Frontiers in Oncology
ObjectiveThis study aimed to analyse the variation of circulating tumour DNA (ctDNA) in patients with hepatocellular carcinoma (HCC).MethodsNewly diagnosed patients with HCC admitted between March 2022 and October 2023 were prospectively enrolled. Plasma
Songtao Liu, Jingjing Chen, Qiaoxin Wei, Jinhuan Wang, Fang Xiong, Jia Guo, Yang Wang, Mei Liu   +7 more
doaj   +2 more sources

Identification and validation of feature genes using a ferroptosis-informed analytical framework in medulloblastoma [PDF]

Frontiers in Pediatrics
BackgroundThis study aimed to identify potential biomarker signatures for medulloblastoma using a ferroptosis-informed analytical framework.MethodsTranscriptomic data from GEO datasets were used to identify differentially expressed ferroptosis-associated
Xin Chen, Sen Li, Kunfang Yang, Yu Liu, Qijia Zhan   +4 more
doaj   +2 more sources

Combining single cell and bulk transcriptomics with Mendelian randomization identifies gut microbiota related prognostic genes and mechanisms in thyroid cancer [PDF]

Discover Oncology
Background Imbalance in gut microbiota (GM) may play a role in the development of thyroid cancer (TC), but the specific mechanisms remain unclear. This study aimed to identify prognostic genes associated with both TC and GM and investigate the underlying
Xiangyu Wang, Bing Wang, Shimei Ding, Tao Wu, Wei Qu, Long Zheng   +5 more
doaj   +2 more sources

LRP1B Mutation Is Associated With Lymph Node Metastasis in Endometrial Carcinoma: A Clinical Next-Generation Sequencing Study

International Journal of Biological Markers
Background This study aims to investigate the mutation status and protein expression of low-density lipoprotein receptor-related protein 1B (LRP1B) in endometrial cancer, and analyze its association with lymph node metastasis (LNM) in endometrial cancer.
Yunfeng Zheng
exaly   +2 more sources

Association of LRP1B Mutation With Tumor Mutation Burden and Outcomes in Melanoma and Non-Small Cell Lung Cancer Patients Treated With Immune Check-Point Blockades

Frontiers in Immunology, 2019
Background: Tumor mutation burden (TMB) have been served as the most prevalent biomarkers to predict immunotherapy response. LRP1B (low-density lipoprotein receptor-related protein 1B) is frequently mutated in melanoma, non-small cell lung cancer (NSCLC)
Xin Wang, Wei Chong, Yueliang Yao
exaly   +3 more sources