Results 11 to 20 of about 4,566 (176)

LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types [PDF]

Journal for ImmunoTherapy of Cancer, 2021
Background Low-density lipoprotein receptor-related protein 1b (encoded by LRP1B) is a putative tumor suppressor, and preliminary evidence suggests LRP1B-mutated cancers may have improved outcomes with immune checkpoint inhibitors (ICI).Methods We ...
Ramy Sedhom, Santosh Gupta, Yuan Wu, Jason Zhu, Daniele Marin, Michael R Harrison, Landon C Brown, Matthew D Tucker, Eric B Schwartz, Chester Kao, Matthew K Labriola, Rajan T Gupta, Daniel J George, Emmanuel S Antonarakis, Andrew J Armstrong   +14 more
doaj   +4 more sources

The tumor biological significance of RNF43 and LRP1B in gastric cancer is complex and context-dependent [PDF]

Scientific Reports, 2023
Gastric cancer (GC) is the fifth most common cancer in the world with a poor prognosis. Both RNF43 and LRP1B function as tumor suppressors in the Wnt signaling pathway and have been described to be frequently mutated in GC.
Bente Holm, Stephan Barsuhn, Hans-Michael Behrens, Sandra Krüger, Christoph Röcken   +4 more
doaj   +4 more sources

Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women

Translational Oncology, 2019
Background: Since human papillomavirus (HPV) DNA testing has been promoted as primary screening strategy, the triage method has also evolved from morphological testing to a molecular biomarker detection to improve screening efficiency.
Yunhui Jiang, Chengyi Zhu, Dan He, Qinglei Gao, Xun Tian, Xin Ma, Jun Wu, Bhudev C. Das, Konstantin Severinov, Inga Isabel Hitzeroth, Priya Ranjan Debata, Rong Liu, Liang Zou, Long Shi, Hua Xu, Kaixiu Wang, Yuxian Bao, Leung Ross Ka-Kit, Zeshan You, Zifeng Cui, Zheng Hu   +20 more
doaj   +4 more sources

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. [PDF]

PLoS ONE, 2010
The low-density lipoprotein (LDL) receptor gene family is a highly conserved group of membrane receptors with diverse functions in developmental processes, lipoprotein trafficking, and cell signaling.
Martin F Dietrich, Louise van der Weyden, Haydn M Prosser, Allan Bradley, Joachim Herz, David J Adams   +5 more
doaj   +4 more sources

Potential predictive value of comutant LRP1B and FAT for immune response in non-small cell lung cancer

Translational Oncology, 2022
Background: Preliminary investigation revealed that Low-density lipoprotein receptor-related protein 1b (LRP1B) and FAT atypical cadherin (FAT) family mutation might serve as immune regulators under certain tumor microenvironment. Experimental design: We
Fang Hao, Qing Ma, Diansheng Zhong
doaj   +3 more sources

LRP1B (low density lipoprotein receptor-related protein 1B) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Review on LRP1B, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Prazeres, H, Salgado, C, Duarte, C, Soares, P   +3 more
openaire   +4 more sources

MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells [PDF]

Endokrynologia Polska, 2023
Thyroid cancer (TC) is a common endocrine malignancy, comprising nearly one-third of all head and neck malignancies worldwide. MicroRNAs (miRNAs) have been implicated in the malignant progression of multiple cancers; however, their contribution to thyroid diseases has not been fully explored.This study aimed to illustrate the regulatory mechanism of ...
Yaojie, Hu, Chunying, Zhang, Qing, Chang, Jinghai, Du, Haodong, Lu, Xin, Guo, Wang, Chang, Shiguang, Liu, Chunyou, Chen   +8 more
openaire   +3 more sources

The Mutation and Expression Level of LRP1B are Associated with Immune Infiltration and Prognosis in Hepatocellular Carcinoma

International Journal of General Medicine, 2021
Mengmeng Wang, Zhifan Xiong Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, People’s Republic of ChinaCorrespondence: Zhifan XiongDivision of Gastroenterology, Liyuan ...
Wang M, Xiong Z
doaj   +4 more sources

Co-Mutation of FAT3 and LRP1B in Lung Adenocarcinoma Defines a Unique Subset Correlated With the Efficacy of Immunotherapy [PDF]

Frontiers in Immunology, 2022
Immunotherapy based on immune checkpoint inhibitors (ICIs) have demonstrated remarkable survival benefits and gained regulatory approval in non-small cell lung cancer (NSCLC) patients without an actionable driver mutation, but currently there is no well ...
Mingyu Zhu, Mingyu Zhu, Mingyu Zhu, Mingyu Zhu, Mingyu Zhu, Lu Zhang, Lu Zhang, Haiyan Cui, Haiyan Cui, Qiang Zhao, Qiang Zhao, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Baochao Zhai, Baochao Zhai, Baochao Zhai, Baochao Zhai, Richeng Jiang, Richeng Jiang, Richeng Jiang, Richeng Jiang, Richeng Jiang, Zhansheng Jiang, Zhansheng Jiang, Zhansheng Jiang, Zhansheng Jiang   +27 more
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LRP1B suppresses HCC progression through the NCSTN/PI3K/AKT signaling axis and affects doxorubicin resistance

Genes and Diseases, 2023
Accumulating evidence supports the association of somatic mutations with tumor occurrence and development. We aimed to identify somatic mutations with important implications in hepatocellular carcinoma (HCC) and explore their possible mechanisms.
Xiangyu Zhai, Zhijia Xia, Gang Du, Xinlu Zhang, Tong Xia, Delin Ma, Xiaosong Li, Bin Jin, Hao Zhang   +8 more
doaj   +2 more sources