Results 21 to 30 of about 4,566 (176)

Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2020
Miaomiao Li,1,* Juntao Hu,2,* Riming Jin,3,* Hongxia Cheng,1 Huaping Chen,4 Limin Li,4 Kun Guo1 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People ...
Li M, Hu J, Jin R, Cheng H, Chen H, Li L, Guo K   +6 more
doaj   +4 more sources

LRP1B is a Potential Biomarker for Tumor Immunogenicity and Prognosis of HCC Patients Receiving ICI Treatment

Journal of Hepatocellular Carcinoma, 2022
Yang Cheng,1,2,* Rui Tang,1,* Xiangzhao Li,3 Biao Wang,4 Yanling Cheng,1 Shuzhe Xiao,1 Penghui Sun,5 Wenxuan Yu,2 Cheng Li,2 Xinsheng Lin,2 Yun Zhu2,* 1Digestive Department, Guangzhou Women and Children’s Medical Center, Guangzhou Medical ...
Cheng Y, Tang R, Li X, Wang B, Cheng Y, Xiao S, Sun P, Yu W, Li C, Lin X, Zhu Y   +10 more
doaj   +3 more sources

Integrated environmental and genomic analysis reveals the drivers and genetic mechanisms of agro-climatic adaptation in geese [PDF]

BMC Genomics
Background Adaptation is one of the key processes of animal domestication, environmental pressures will leave footprints in the genome. Geese are widely distributed across multiple geographical conditions with distinct adaptations.
Xiaoli Zhou, Junliang Xia, Weiding Chen, Jiajia Zou, Jiahui Chen, Xiquan Zhang   +5 more
doaj   +2 more sources

Erratum: Chromosomal, epigenetic and microRNA-mediated inactivation of LRP1B, a modulator of the extracellular environment of thyroid cancer cells [PDF]

Oncogene, 2010
The low-density lipoprotein receptor-related protein (LRP1B), encoding an endocytic LDL-family receptor, is among the 10 most significantly deleted genes across 3312 human cancer specimens. However, currently the apparently crucial role of this lipoprotein receptor in carcinogenesis is not clear.
H., Prazeres, J., Torres, F., Rodrigues, M., Pinto, M.C., Pastoriza, D., Gomes, Cameselle Teijeiro, Jose Manuel, Vidal Figueroa, Anxo, T.C., Martins, M., Sobrinho-Simoes, P., Soares   +10 more
openaire   +7 more sources

Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD [PDF]

Scientific Reports, 2017
Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics ...
Dakai Xiao, Fuqiang Li, Hui Pan, Han Liang, Kui Wu, Jianxing He   +5 more
doaj   +2 more sources

Mecanismos de inactivação do gene LRP1B em tumores da tiróide [PDF]

, 2009
Thyroid tumours are the most frequent type of endocrine neoplasia and can occur in both sporadic and familial forms. LRP1B is a potential tumour suppressor gene and its role has never been adressed in thyroid. Tumour suppressor genes can be inactivated by a number of different mechanisms, namely epigenetic events.
Torres, Joana Antunes
core   +3 more sources

Integrated Genomic, Transcriptomic, and Circulating Biomarkers Predict Benefit to Immune Checkpoint Inhibitor Plus Chemotherapy in Advanced Non-Small Cell Lung Cancer. [PDF]

MedComm (2020)
This multi‐omics study identified biomarkers associated with clinical benefit from first‐line ICI plus chemotherapy in advanced NSCLC. LRP1B mutations and high IL24 expression correlated with longer progression‐free survival, whereas FBXW7 mutations, high SPP1 or LHCGR expression, and on‐treatment ctDNA positivity were associated with poor prognosis ...
Li L, Han D, Zhang X, Zhou H, Li J, Tian T, Bai R, Xu K, Xu Y, He C, Xu L, Wang H, Tang H, Wei S, Li J, He R, Niu S, Gao X, Wang F, Jing Q, Yin J, Xu L, Xu L, Zhang ZH.   +23 more
europepmc   +2 more sources

Development and validation of LRP1B mutation-associated prognostic model for hepatocellular carcinoma [PDF]

Bioscience Reports, 2021
Abstract Purpose: To develop a lipoprotein receptor-related protein 1B (LRP1B) gene mutation-based prognostic model for hepatocellular carcinoma (HCC) patients risk prediction. Methods: The LRP1B gene mutation rate was calculated from HCC patient samples.
Jian Xu, Xiaomin Shen, Bo Zhang, Rui Su, Mingxuan Cui, Li Yan, Yu Cao   +6 more
openaire   +3 more sources

Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer [PDF]

Computational and Mathematical Methods in Medicine, 2021
Background. It has been shown that low-density lipoprotein receptor-related protein 1B (LRP1B) mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between LRP1B mutations and TMB in gastric cancer needs further study.
Sizhe Hu, Xiaokang Zhao, Feng Qian, Cancan Jin, Kaishun Hou   +4 more
openaire   +2 more sources

Identification of LRP1b domains involved in receptor function

, 2021
Diese Dissertation widmet sich den Funktionen des LRP1b-Rezeptors, einem großen Mitglied der LDL-Rezeptorfamilie. Während meiner Dissertation wurden mehrere in vivo und in vitro Experimente durchgeführt, um zu einem besseren Verständnis der Funktion ...
Mair, Fabian
core   +3 more sources