Results 41 to 50 of about 4,566 (176)

Genomic Organization of a New Candidate Tumor Suppressor Gene, LRP1B

Genomics, 2000
LRP1B is a novel candidate tumor suppressor gene that is inactivated by genetic and transcript alterations in nearly 50% of non-small-cell lung cancer cell lines. The gene-encoded protein is highly homologous to the gigantic lipoprotein receptor-related protein 1 (LRP1) that belongs to the family of low-density lipoprotein receptors.
C X, Liu, S, Musco, N M, Lisitsina, S Y, Yaklichkin, N A, Lisitsyn   +4 more
openaire   +2 more sources

Supplementary Table 3 - LRP1B as a potential gastric cancer biomarker

, 2023
Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins
Ji Miao (739159), Peng Song (281947), Wenxian Guan (419493), Wen Guo (112664), Chao Ding (9055784), Zhi Yang (124104), Lixiang Liu (489374)   +6 more
core   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas. [PDF]

J Pathol
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Ermakov MS, Filipe JF, Eidenhammer S, Ott G, Halbwedl I, Kashofer K, Popper H.   +6 more
europepmc   +2 more sources

Supplementary Figure 1 - LRP1B as a potential gastric cancer biomarker

, 2023
Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins
Ji Miao (739159), Peng Song (281947), Wenxian Guan (419493), Wen Guo (112664), Chao Ding (9055784), Zhi Yang (124104), Lixiang Liu (489374)   +6 more
core   +1 more source

Supplementary Methods - LRP1B as a potential gastric cancer biomarker

, 2023
Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins
Ji Miao (739159), Peng Song (281947), Wenxian Guan (419493), Wen Guo (112664), Chao Ding (9055784), Zhi Yang (124104), Lixiang Liu (489374)   +6 more
core   +1 more source

Supplementary Table 1 - LRP1B as a potential gastric cancer biomarker

, 2023
Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins
Ji Miao (739159), Peng Song (281947), Wenxian Guan (419493), Wen Guo (112664), Chao Ding (9055784), Zhi Yang (124104), Lixiang Liu (489374)   +6 more
core   +1 more source

Multi‐omics data identified TP53 and LRP1B as key regulatory gene related to immune phenotypes via EPCAM in HCC

Cancer Medicine, 2022
Background Many studies showed that the prognosis of hepatocellular carcinoma (HCC) was significantly associated with the expressions of TP53 and LRP1B. However, the potential influence of the two genes on the malignant progression of HCC is still to be ...
Liang Shi, Jie Cao, Xin Lei, Yifen Shi, Lili Wu   +4 more
doaj   +1 more source

TP53 Exon 5 Mutation Indicates Poor Progression-Free Survival for Patients with Stage IV NSCLC

Frontiers in Bioscience-Landmark, 2023
Background: Genetic mutations are quite common in non-small cell lung cancer (NSCLC), however, their prognostic value remains controversial. Methods: This study explored the mutational landscape of tumor samples from patients with advanced NSCLC by next ...
Huijing Feng, Huiru Xu, Xiuhuan Shi, Guobin Ding, Cihui Yan, Linhan Li, Zuoyi Jian, Xuejing Yang, Hongxia Guo, Feng Li, Junping Zhang, Xiubao Ren   +11 more
doaj   +1 more source

LRP1B mutation: a novel independent prognostic factor and a predictive tumor mutation burden in hepatocellular carcinoma [PDF]

Journal of Cancer, 2021
Hepatocellular carcinoma (HCC) is one of the most common malignancies globally and the second leading cause of cancer-related death. Low-density lipoprotein (LDL) receptor-related protein 1B (LRP1B) is one of the commonly mutated genes in HCC, but its role in HCC remains unclear. In this study, we analyzed the role of LRP1B mutation in HCC.
Liu, Fahui, Hou, Wanyun, Liang, Jiadong, Zhu, Lilan, Luo, Chunying   +4 more
openaire   +2 more sources

Prognosis and personalized medicine prediction by integrated whole exome and transcriptome sequencing of hepatocellular carcinoma

Frontiers in Genetics, 2023
Hepatocellular carcinoma (HCC) is a clinically and genetically heterogeneous disease. To better describe the clinical value of the main driver gene mutations of HCC, we analyzed the whole exome sequencing data of 125 patients, and combined with the ...
Debao Li, Debao Li, Debao Li, Lei Lei, Jinsong Wang, Bo Tang, Jiuling Wang, Rui Dong, Wenjiong Shi, Guo Liu, Tingting Zhao, Tingting Zhao, Yuzhang Wu, Yuzhang Wu, Yuzhang Wu, Yi Zhang, Yi Zhang   +16 more
doaj   +1 more source