Results 61 to 70 of about 4,566 (176)

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

open access: yesVIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding   +10 more
wiley   +1 more source

Paired comparisons of mutational profiles before and after brachytherapy in asian uveal melanoma patients

open access: yesScientific Reports, 2021
Uveal melanoma(UM) is the most common primary intraocular malignancy in adults. However, the incidence of UM in Asia is 10 to 20 times less than in Western populations.
Woo Seung Lee   +5 more
doaj   +1 more source

Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement

open access: yesCurrent Oncology, 2021
The autopsy of a 65-year-old diabetic African American male revealed significant left myocardial involvement by adult T-cell leukemia/lymphoma (ATLL) despite normal pre-mortem fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed ...
Taraneh Hashemi Zonouz   +3 more
doaj   +1 more source

Genome‐Wide Association Studies for Anogenital Distance and Linear Type Traits in Gir Cattle

open access: yesJournal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Although linear type traits have been under selection in the Dairy Gir cattle for the past three decades, there are few studies exploring genetic architecture for these traits. The aim of this study was to identify candidate genes for anogenital distance and linear type traits in the Gir breed. For this study, the body measures of rump length (
Renata de Fátima Bretanha Rocha   +8 more
wiley   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

open access: yesInternational Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat   +14 more
wiley   +1 more source

Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China

open access: yesBMC Medical Genomics, 2022
Purpose This study aimed to analyse the genomic alteration profiles and immune characteristics of a cohort of Chinese cervical cancer patients to understand why certain patients benefited from molecular targeted therapies and immunotherapy as well as ...
Jing Liu   +9 more
doaj   +1 more source

Utilizing Proteomic Approaches to Uncover the Neuroprotective Effects of ACE Inhibitors: Implications for Alzheimer’s Disease Treatment

open access: yesMolecules, 2023
Two types of angiotensin-converting enzyme (ACE) inhibitors, lisinopril and benazepril HCl, were tested in neuroblastoma cells and found to upregulate low-density lipoprotein-receptor-related protein 1B (LRP1B) and 14-3-3 protein zeta/delta. Additionally,
Ming-Hui Yang   +6 more
doaj   +1 more source

Generation of Lrp1b null alleles.

open access: yes, 2013
(A) Duplication of N-terminal exons 6-8 to generate the Lrp1btm1wtsi allele and Southern blot hybridization after EcoRV digestion of embryonic stem cell genomic DNA to verify targeting of the allele.
Louise van der Weyden (119180)   +5 more
core   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

open access: yesInternational Journal of Cancer, Volume 159, Issue 9, Page 2290-2299, 1 November 2026.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel   +26 more
wiley   +1 more source

Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information

open access: yesJournal of Animal Breeding and Genetics, Volume 143, Issue 6, Page 774-783, November 2026.
ABSTRACT The Finnish Ayrshire cattle belong to the Nordic Red breeds. The basis of selection in Nordic Red breeds shifted from traditional pedigree‐based breeding values to genomic breeding values between 2011 and 2014. Joint genetic evaluation and admixture among the Nordic Red breeds have led to the formation of a composite Nordic Red population ...
Katri Sarviaho   +4 more
wiley   +1 more source

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