Results 81 to 90 of about 4,566 (176)

Comprehensive Mutation Profiling of Colorectal Cancer Patients With Lung or Liver Metastasis by Targeted Next-Generation Sequencing

Technology in Cancer Research & Treatment, 2023
Objectives Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there is an incomplete understanding of the discrepancies in the genomic profiles between primary tumors and metastases, such
Chun-Ting Hu PhD, Jing-Long Wang MD, Ting Hou MD, Zhao-Wen Yan MD, Li-Dong Zu PhD, Guo-Hui Fu PhD, Wei-Wei Shen PhD   +6 more
doaj   +1 more source

S1‐Leitlinie Schweißdrüsenkarzinom

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 9, Page 1356-1384, September 2026.
Zusammenfassung Die aktuelle Einteilung der Schweißdrüsenkarzinome erfolgt nach histomorphologischen Charakteristika und unterscheidet mehr als 20 Entitäten. Es sind meist Patienten höheren, bei einigen Subtypen aber auch mittleren und jüngeren, Lebensalters betroffen. Die Mehrheit der Tumoren entsteht de novo.
Mirjana Ziemer, Michael Erdmann, Abbas Agaimy, Jürgen C. Becker, Almut Böer‐Auer, Doris Helbig, Cornelia Erfurt‐Berge, Alexander Frisman, Conrad Hempel, Ulrike Leiter, Friedegund Meier, Thomas Mentzel, Lara Racz, Silke Redler, Stefan Schliep, Clemens Seidel, Alpaslan Tasdogan, Jochen Utikal, Carsten Weishaupt, Selma Ugurel   +19 more
wiley   +1 more source

Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis

BMC Cancer, 2021
Background Identifying gene mutation signatures will enable a better understanding for the occurrence and development of colorectal cancer (CRC), and provide some potential biomarkers for clinical practice.
Yan Zhuang, Hailong Wang, Da Jiang, Ying Li, Lixia Feng, Caijuan Tian, Mingyu Pu, Xiaowei Wang, Jiangyan Zhang, Yuanjing Hu, Pengfei Liu   +10 more
doaj   +1 more source

S1 guideline sweat gland carcinoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 9, Page e1356-e1385, September 2026.
Summary The current classification of sweat gland carcinomas is based on histomorphological characteristics and distinguishes between more than 20 entities. Most patients are older, but some subtypes also affect middle‐aged and younger patients. The majority of tumors arise de novo. Sweat gland carcinomas have nonspecific clinical features.
Mirjana Ziemer, Michael Erdmann, Abbas Agaimy, Jürgen C. Becker, Almut Böer‐Auer, Doris Helbig, Cornelia Erfurt‐Berge, Alexander Frisman, Conrad Hempel, Ulrike Leiter, Friedegund Meier, Thomas Mentzel, Lara Racz, Silke Redler, Stefan Schliep, Clemens Seidel, Alpaslan Tasdogan, Jochen Utikal, Carsten Weishaupt, Selma Ugurel   +19 more
wiley   +1 more source

Therapeutic and Predicted Significance of PKLR in Patients With Cholangiocarcinoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy with a poor prognosis. However, the molecular mechanisms underlying CCA and its treatment options remain unclear and limited. Aims This study aims to identify novel prognostic biomarkers and potential therapeutic targets for CCA through transcriptomics and whole‐exome ...
Biyan Gong, Xuejun Xu, Tubing Xu, Dong Zhang, Li Yang, Cailing Li, Tingjun Li, Yuandeng Luo   +7 more
wiley   +1 more source

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

, 2012
Fulltext embargoed for: 12 months post date of publicationHigh-grade serous cancer (HGSC), the most common subtype of ovarian cancer, often becomes resistant to chemotherapy, leading to poor patient outcomes.
Hendley, J, Christie, EL, Cullinane, C, Heinzelmann-Schwarz, V, Ftouni, S, Bowtell, DDL, Friedlander, M, Anglesio, MS, Campbell, P, Pearson, RB, Van Loo, P, George, J, McNally, O, Quinn, M, DeFazio, A, Etemadmoghadam, D, Galletta, L, Cowin, PA, Fereday, S, Bowes, L, Sheppard, KE, Harnett, PR, Loehrer, E, Heinzelmann-Schwarz, Viola, Harnett, Paul R., Australian Ovarian Cancer Study, Bowtell, David D.L., Anglesio, Michael S., Galletta, Laura, deFazio, Anna, Pearson, Richard B., Cullinane, Carleen, Etemadmoghadam, Dariush, George, Joshy, Loehrer, Elizabeth, Ftouni, Sarah, Bowes, Leanne, Campbell, Peter, Hendley, Joy, Quinn, Michael, Friedlander, Michael, McNally, Orla, Cowin, Prue A., Christie, Elizabeth L., Van Loo, Peter, Fereday, Sian, Sheppard, Karen E.   +46 more
core   +4 more sources

Two Secondary Introductions From a Shared Bridgehead Population Show Evidence of Divergent and Parallel Selection

Molecular Ecology, Volume 35, Issue 15, August 2026.
ABSTRACT Biological invasions offer large‐scale experiments for examining rapid evolution and testing the predictability of adaptive change. Assessing the repeatability of such adaptive responses, however, requires replicated introductions that share similar demographic and environmental contexts. Single introduction events are common during biological
Adi Nugroho, Sebastien Comte, Patrick Barrière, Robert B. Allen, William B. Sherwin, Lee A. Rollins   +5 more
wiley   +1 more source

LRP1B associated with immune cell infiltration influenced the efficacy of immunotherapy in colorectal cancer patients. [PDF]

Clinics (Sao Paulo)
Colorectal cancer is one of the most common malignant tumors in the world, which seriously threatens human health. It is essential for the search for new oncogene targets in colorectal cancer.Samples from 57 colorectal cancer patients were collected in this study.
Weng W, He S, Zhang G, Zhou X, Li K, Lai J.   +5 more
europepmc   +4 more sources

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, Volume 13, Issue 38, 9 July 2026.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Estudo da expressão da proteína LRP1B em tumores de ovário [PDF]

, 2019
O LRP1B (Recetor de lipoproteína de baixa densidade ligado à proteína 1B), pertencente à superfamília de recetores de lipoproteína de baixa densidade, interage com vários ligandos e serve como mediador da endocitose.
Cunha, Ana Isabel Ribeiro da
core