Results 71 to 80 of about 4,566 (176)

Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma

Experimental Hematology & Oncology, 2022
Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal tract. Previous reports have revealed that primary gastrointestinal-DLBCL (pGI-DLBCL)
Shan-Shan Li, Xiao-Hui Zhai, Hai-Ling Liu, Ting-Zhi Liu, Tai-Yuan Cao, Dong-Mei Chen, Le-Xin Xiao, Xiao-Qin Gan, Ke Cheng, Wan-Jia Hong, Yan Huang, Yi-Fan Lian, Jian Xiao   +12 more
doaj   +1 more source

Multi‐site sequencing supports dual‐track evolution and identifies candidate metastasis‐associated factors in gastric cancer ovarian metastasis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Multi‐site whole‐exome sequencing and phylogenetic reconstruction characterise gastric cancer ovarian metastasis. Lymph node‐dependent and lymph node‐independent evolutionary patterns coexist across patients. SCAF4 is nominated as a candidate metastasis‐associated factor supported by genomic and loss‐of‐function evidence.
Peiyu Zhu, Xiaofang Xing, Ke Ji, Lingqian Wang, Zhongwu Li, Shuqin Jia, Longtao Huangfu, Xiaomei Li, Biao Fan, Zhaode Bu, Jiafu Ji   +10 more
wiley   +1 more source

NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer

Frontiers in Immunology, 2022
BackgroundPatients with early-stage laryngeal cancer, even stage T1-2N0, are at considerable risk of recurrence and death. The genetic and immunologic characteristics of recurrent laryngeal cancer remain unclear.MethodsA total of 52 T1-2N0 laryngeal ...
Xiao-yang Gong, Hai-bin Chen, Li-qing Zhang, Dong-sheng Chen, Wang Li, Dong-hui Chen, Jin Xu, Han Zhou, Le-le Zhao, Yun-jie Song, Ming-zhe Xiao, Wang-long Deng, Chuang Qi, Xue-rong Wang, Xi Chen   +14 more
doaj   +1 more source

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

Glia, Volume 74, Issue 9, September 2026.
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko, Shu‐Hui Chu, Angela Gomez‐Arboledas, Blossom Zhang, Andrea J. Tenner   +4 more
wiley   +1 more source

DataSheet_1_Co-Mutation of FAT3 and LRP1B in Lung Adenocarcinoma Defines a Unique Subset Correlated With the Efficacy of Immunotherapy.docx

, 2022
Immunotherapy based on immune checkpoint inhibitors (ICIs) have demonstrated remarkable survival benefits and gained regulatory approval in non-small cell lung cancer (NSCLC) patients without an actionable driver mutation, but currently there is no well ...
Qiang Zhao (105948), Richeng Jiang (11912018), Zhansheng Jiang (11912021), Mingyu Zhu (3195627), Lu Zhang (50563), Haiyan Cui (406207), Baochao Zhai (11912015), Hao Wang (39217)   +7 more
core   +1 more source

Integrative Multi‐Omics Profiling Reveals Age‐Associated Genomic and Tumor Microenvironmental Heterogeneity in Colorectal Cancer

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Integrated multi‐omics analysis defines an age‐resolved molecular–immune framework in colorectal cancer. Early‐onset tumors show reduced APC/KRAS alterations, frequent SMAD4 disruption, enriched PTPRK–RSPO3 fusions, and increased CD4+ memory T cells and mast cells with greater checkpoint responsiveness.
Yang Guo, Yajiao He, Tao Zhou, Haidong Zhang, Fei Liao, Yuelan Wang, Hai‐Ning Chen, Li‐Bin Huang, Xuyang Xia, Yiqi Deng, Jing Wu, Siyu Yang, Heng Xu, Zong‐Guang Zhou, Yang Shu, Lie Yang   +15 more
wiley   +1 more source

Pembrolizumab in men with heavily treated metastatic castrate‐resistant prostate cancer

Cancer Medicine, 2019
Background Pembrolizumab is approved for patients with metastatic, microsatellite instability (MSI)‐high or mismatch repair‐deficient (dMMR) solid tumors. However, very few men with prostate cancer were included in these initial studies.
Matthew D. Tucker, Jason Zhu, Daniele Marin, Rajan T. Gupta, Santosh Gupta, William R. Berry, Sundhar Ramalingam, Tian Zhang, Michael Harrison, Yuan Wu, Patrick Healy, Stacey Lisi, Daniel J. George, Andrew J. Armstrong   +13 more
doaj   +1 more source

Targeting immune cell types of tumor microenvironment to overcome resistance to PD-1/PD-L1 blockade in lung cancer

Frontiers in Pharmacology, 2023
Lung cancer is the common malignant tumor with the highest mortality rate. Lung cancer patients have achieved benefits from immunotherapy, including immune checkpoint inhibitors (ICIs) therapy.
Man Wang, Lijie Zhu, Xiaoxu Yang, Jiahui Li, Yu’e Liu, Ying Tang   +5 more
doaj   +1 more source

Molecular Mechanisms and Therapeutic Applications of Extracellular Vesicles in Remodeling of the Skin Cancer Niche

Nano Select, Volume 7, Issue 9, September 2026.
Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian, Maria Nison, Deepanjan Datta, Soniya Kumbham, Namdev Dhas, Praveen Halagali, Vasudev R Pai, Vamshi Krishna Tippavajhala   +7 more
wiley   +1 more source

Association between Variants in Atopy-Related Immunologic Candidate Genes and Pancreatic Cancer Risk.

PLoS ONE, 2015
BackgroundMany epidemiology studies report that atopic conditions such as allergies are associated with reduced pancreas cancer risk. The reason for this relationship is not yet understood.
Michelle Cotterchio, Elizabeth Lowcock, Zoe Bider-Canfield, Mathieu Lemire, Celia Greenwood, Steven Gallinger, Thomas Hudson   +6 more
doaj   +1 more source