Results 91 to 100 of about 4,566 (176)

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, Volume 36, Issue 4, July 2026.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

Integrative clinical and molecular analysis of advanced biliary tract cancers on immune checkpoint blockade reveals potential markers of response

Clinical and Translational Medicine, 2020
Background While there have been encouraging preliminary clinical results for immune checkpoint inhibitors (ICIs) in BTCs, it remains a challenge to identify the subset of patients who may benefit.
Jingjing Li, Qing Wei, Xiaoying Wu, Jun Sima, Qi Xu, Mengmeng Wu, Fufeng Wang, Haibo Mou, Hanguang Hu, Jianguo Zhao, Da Li, Jinlin Hu, Lingnan Zhang, Xiu Zhu, Lei Chen, Cong Luo, Junrong Yan, Jiachen He, Yutong Ma, Yang Shao, Wei Wu, Jieer Ying   +21 more
doaj   +1 more source

Additional file 5 of Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma

, 2022
Additional file 5: Table S5.
Hai-Ling Liu (4408348), Dong-Mei Chen (1712968), Le-Xin Xiao (13963923), Xiao-Qin Gan (13963926), Yan Huang (46805), Yi-Fan Lian (3214935), Ting-Zhi Liu (3370514), Tai-Yuan Cao (13963920), Xiao-Hui Zhai (11880669), Ke Cheng (161778), Wan-Jia Hong (13963929), Jian Xiao (253329), Shan-Shan Li (436534)   +12 more
core   +1 more source

Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances.

, 2020
International audienceMotor disturbances strongly increase the burden of cocaine use disorder (CUDs). The objective of our translational study was to identify the genes and biological pathways underlying the tolerance to cocaine-induced motor effects. In
Vorspan, Florence, Bloch, Vanessa, Laplanche, Jean-Louis, Firmo, Cyril, Prince, Nathalie, Mekdad, Nawel, Icick, Romain, Mégarbane, Bruno, Bellivier, Frank, Pishalin, Dmitry, Marie-Claire, Cynthia, Benturquia, Nadia, Courtin, Cindie, Blugeon, Corinne, Cindie Courtin, Nathalie Prince, Jean-Louis Laplanche, Nawel Mekdad, Romain Icick, Cyril Firmo, Dmitry Pishalin, Cynthia Marie-Claire, Corinne Blugeon, Vanessa Bloch, Florence Vorspan, Frank Bellivier, Nadia Benturquia, Bruno Mégarbane   +27 more
core   +1 more source

Blastocyst outgrowth assay.

, 2013
Time course of Lrp1b wildtype (Lrp1b+/+) compared to Lrp1b knockout (Lrp1btm1wtsi/tm2wtsi) trophoblast explant growth, showing expansion of inner cell mass and trophoblast formation. Images were taken on days 1, 2, 4, and 6.
Louise van der Weyden (119180), David J. Adams (119198), Joachim Herz (28421), Martin F. Dietrich (365195), Allan Bradley (30345), Haydn M. Prosser (167465)   +5 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes

Genome Medicine
Background Rare oncogenic driver events, particularly affecting the expression or splicing of driver genes, are suspected to substantially contribute to the large heterogeneity of hematologic malignancies.
Xueqi Cao, Sandra Huber, Ata Jadid Ahari, Franziska R. Traube, Marc Seifert, Christopher C. Oakes, Polina Secheyko, Sergey Vilov, Ines F. Scheller, Nils Wagner, Vicente A. Yépez, Piers Blombery, Torsten Haferlach, Matthias Heinig, Leonhard Wachutka, Stephan Hutter, Julien Gagneur   +16 more
doaj   +1 more source

Identification of nomogram associated with durable clinical benefit gene for advanced non-small cell lung cancer with sensitivity to responsive to immunotherapy

Heliyon
Background: Immunotherapy has become the standard treatment for advanced non-small cell lung cancer (NSCLC). However, a subset of the most advanced NSCLC patients fails to respond adequately to Immune checkpoint inhibitors (ICIs).
Li Wang, Xiangling Chu, Xin Yu, Chunxia Su   +3 more
doaj   +1 more source

Evaluation of the role of LRP1B in the response of human ovarian cancer cells to liposomal doxorubicin [PDF]

, 2019
RESUMO: Avanços no conhecimento dos mecanismos associados ao cancro levaram ao desenvolvimento de vários fármacos e nanotransportadores que potenciam a entrega de fármacos ultrapassando algumas limitações.
Saraiva, Inês de Andrade Matos Gonçalves
core  

The Putative Tumor Suppressor LRP1B, a Novel Member of the Low Density Lipoprotein (LDL) Receptor Family, Exhibits Both Overlapping and Distinct Properties with the LDL Receptor-related Protein

, 2001
The low density lipoprotein receptor-related protein-deleted in tumor (LRP1B, initially referred to as LRP-DIT) was cloned and characterized as a candidate tumor suppressor. It is a new member of the low density lipoprotein receptor gene family.
Obermoeller-McCormick, Lynn M., Li, Yonghe, Bu, Guojun, Schwartz, Alan L., Liu, Chun Xiang   +4 more
core   +1 more source