Results 51 to 60 of about 4,566 (176)

LRP1B affects lung adenocarcinoma immunotherapy efficacy via ferroptosis

, 2023
AbstractBackground Currently, the clinically used immune biomarkers for non-small cell lung cancer (NSCLC) are programmed death ligand 1 (PD-L1) and tumor mutation burden (TMB). However, they cannot accurately predict the effectiveness of immunotherapy.
zihao ke, tao yu, qi zhang, ying chen, kaihua lu   +4 more
openaire   +1 more source

Investigation of Genetic Mutations in High-risk and Low-risk Basal Cell Carcinoma in a Non-Caucasian Population by Whole Exome Sequencing

Acta Dermato-Venereologica, 2021
This study analysed genomic mutations in basal cell carcinoma using whole exome sequencing of DNA specimens obtained from 20 Korean patients. Histological evaluation determined that 15 (75%) were low-risk basal cell carcinomas, and 5 (25%) were high-risk
Hyun Jee Kim, Minho Lee, Young Bok Lee, Dong Soo Yu   +3 more
doaj   +1 more source

miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer [PDF]

Bioscience Reports, 2019
AbstractAccumulating evidence suggests that miRNAs play a crucial role in the development of prostate cancer (PC); however, the role of miR-500 in PC remains poorly understood. The data presented here reveal abnormal increases in miR-500 expression in PC tissues and cell lines. Suppression of miR-500 expression significantly inhibited the proliferation
Zhaoli Zhang, Ran Cui, Hui Li, Jinlong Li   +3 more
openaire   +2 more sources

Genotyping of Lrp1b heterozygous intercrosses.

, 2013
Genotyping data at 4 wks, E8.5 and E10.5 was performed on genomic DNA from intercrosses of Lrp1btm2wtsi mice, whereas genotyping of the E3.5s was performed on genomic DNA from intercrosses of Lrp1btm1wtsi with Lrp1btm2wtsi mice.
Louise van der Weyden (119180), David J. Adams (119198), Joachim Herz (28421), Martin F. Dietrich (365195), Allan Bradley (30345), Haydn M. Prosser (167465)   +5 more
core   +1 more source

Expression of Lrp1b and Lrp4 ECDs.

, 2013
Whole brain lysates (50 µg) from (A) Lrp1b and (B) Lrp4 truncation mutants were analyzed for expression of the ECD. For the Lrp1b truncation (“Lrp1b EC Stop”), the ECD is expressed at approximately the same size as the full-length receptor (“Wt”) due to ...
Louise van der Weyden (119180), David J. Adams (119198), Joachim Herz (28421), Martin F. Dietrich (365195), Allan Bradley (30345), Haydn M. Prosser (167465)   +5 more
core   +1 more source

Supplementary Material for: LRP1B Expression as a Putative Predictor of Response to Pegylated Liposomal Doxorubicin Treatment in Ovarian Cancer

, 2021
Background: Pegylated liposomal doxorubicin (PLD) is among the most active therapies for recurrent/progressive ovarian cancer (OC). Low-density lipoprotein receptor-related protein 1B (LRP1B) is one of the 10 most significantly deleted genes in human ...
Guimarães M. (11595796), Cunha A.I. (11595784), Lima R.T. (11595802), DionísiodeSousa I.J. (11595781), Soares P. (7904045), Gimba E.R.P. (11595793), Saraiva I.A. (11595787), Prazeres H. (11595799), Lopes J.M. (11461303), Portugal R.V. (11595790)   +9 more
core   +1 more source

Downregulation of Low-density lipoprotein receptor-related protein 1B (LRP1B) inhibits the progression of hepatocellular carcinoma cells by activating the endoplasmic reticulum stress signaling pathway

, 2022
Hepatocellular carcinoma (HCC) has a high recurrence rate and mortality rate even after surgery. Low-density lipoprotein receptor-related protein 1B (LRP1B) has proven to be involved in tumor development and progression of multiple malignancies. However,
Zili Zhen (10001731), Peilong Sun (5017982), Zhemin Shen (4726800)   +2 more
core   +1 more source

A comprehensive analysis of somatic alterations in Chinese ovarian cancer patients

Scientific Reports, 2021
Ovarian cancer is one of the most common cancers in women and is often diagnosed as advanced stage because of the subtle symptoms of early ovarian cancer.
Yingli Zhang, Xiaoliang Shi, Jiejie Zhang, Xi Chen, Peng Zhang, Angen Liu, Tao Zhu   +6 more
doaj   +1 more source

Case Report: Genetic profiling of small intestine metastasis from poorly differentiated non-small cell lung cancer: report of 2 cases and literature review of the past 5 years

Frontiers in Oncology, 2023
BackgroundPoorly differentiated non-small cell lung cancer (NSCLC) is characteristic of high rate of distant metastasis and late stages at diagnosis.
Mengqin Wang, Gang Chen, Jiang Luo, Zhipeng Fan, Yuying Liu, Conghua Xie, Conghua Xie, Yan Gong, Yan Gong   +8 more
doaj   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source