Results 241 to 250 of about 711,573 (395)

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Three-year outcomes of tumor necrosis factor alpha inhibitor therapy in rheumatoid arthritis patients with elevated liver enzymes. [PDF]

World J Hepatol
Duggal S, Kattamuri L, Sairam S.
europepmc   +1 more source

Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells. [PDF]

, 1998
Akashi, Androlewicz, Black, Browning, Browning, Browning, Chaturvedi, Chiacchia, Crowe, De Togni, Decoster, Engelmann, English, Espevik, Espevik, Estrov, Fiers, Fransen, Hass, Huylebroeck, Koni, Kriegler, Krönke, Lewis, Lucas, Mackay, Mantovani, Matthews, Mellow, Moss, Müller, Nedospasov, Olsen, Paul, Southern, Spies, Steer, Sung, Tada, Tang, Tartaglia, Tartaglia, Tartaglia, Tartaglia, Vandenabeele, Vanhaesebroeck, Vanhaesebroeck, Vercammen, Vilček   +48 more
core   +2 more sources

Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors. [PDF]

, 1991
Edouard Vannier, Laurie C. Miller, C A Dinarello   +2 more
openalex   +1 more source

CCL5hi Macrophages Interact with CD8+ T Cells and Potentiate Responsiveness to PD‐1 Blockade Plus Chemotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study has characterized a functionally distinct macrophage subset, termed CCL5hi macrophages, and elucidated the underlying mechanisms of a regulatory feedback loop that interconnects IFN‐γ, CCL5hi macrophages, and CD8+ T cells within the TME of ESCC undergoing immunochemotherapy.
Yuanzhen Ma, Xiaodong Su, Tingting Zeng, Chunlian Zhou, Guozhen Yang, Zengfei Xia, Chufeng Zeng, Jiarong Zhan, Xin‐Yuan Guan, Xu Zhang, Yan Li   +10 more
wiley   +1 more source

Kv11.1-dependent senescence activates a lethal immune response via tumor necrosis factor alpha. [PDF]

Neoplasia
Saatloo MV, Delisi D, Eskandari N, Krieg C, Gentile S.   +4 more
europepmc   +1 more source

Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats.

Circulation, 1998
B. Bozkurt, S. Kribbs, F. Clubb, L. Michael, V. Didenko, P. Hornsby, Y. Seta, H. Oral, F. Spinale, D. Mann   +9 more
semanticscholar   +1 more source

Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages. [PDF]

, 1991
Christian Drouet, Alexander N. Shakhov, C. Victor Jongeneel   +2 more
openalex   +1 more source

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha Inhibitor-Induced Sarcoid-Like Reaction in a Patient With Juvenile Idiopathic Arthritis: A Case Report. [PDF]

Cureus
Aung T, Prasanpanich M, Kaplan A, Eblen K, Fishbein GA.   +4 more
europepmc   +1 more source