Results 241 to 250 of about 729,544 (396)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Role of red cell distribution width, tumor necrosis factor-alpha, and interleukin-6 in immunoglobulin a vasculitis nephritis among Tibetan children in high-altitude areas. [PDF]

BMC Pediatr
Xu C, Cui W, Zeng C, Baima Y, Baima Y, Deng F, Dawa Q, Xu Y.   +7 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Therapeutic Potential of 7,8-Dimethoxycoumarin in Tumor Necrosis Factor-Alpha-Induced Trigeminal Neuralgia in a Rat Model. [PDF]

Curr Issues Mol Biol
Paramakrishnan N, Raadhika K, Elayaperumal S, Sivamani Y, Paramaswaran Y, Siang LJ, Venkata Rathina Kumar T, Lim KG, Ramesh M, Muthuraman A.   +9 more
europepmc   +1 more source

Effectiveness and Tolerability of Anti-Tumor Necrosis Factor Alpha Therapy in Refractory Intestinal Behçet’s Disease: A Large Single-Center Study

Ji Young Chang, Jiwoo Kim, Soo Jung Park, Jae Jun Park, Tae-Il Kim, Jae Hee Cheon, Jihye Park   +6 more
openalex   +1 more source

Tumor Necrosis Factor-.ALPHA. Expression and Kupffer Cell Activation in Hepatotoxicity Caused by Microcystin-LR in Mice.

, 2001
Toshinori Yoshida, Makio Takeda, Tomoaki Tsutsumi, Satoshi Nagata, Fuyuko Yoshida, Keizo Maita, Takanori Harada, Yoshio Ueno   +7 more
openalex   +2 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha and Its Association With Breast Cancer: A Systematic Review. [PDF]

World J Oncol
Qodir N, Pramudhito D, Legiran, Hafy Z, Iman MB, Syafira F, Afladhanti PM, Daenasa RS, Indra B.   +8 more
europepmc   +1 more source

The Role of Therapeutic Drug Monitoring of Anti–Tumor Necrosis Factor Alpha Agents in Children and Adolescents with Inflammatory Bowel Disease [PDF]

, 2015
Maria E. Joosse, Janneke N. Samsom, C. Janneke van der Woude, Johanna C. Escher, Teun van Gelder   +4 more
openalex   +1 more source

Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats.

Circulation, 1998
B. Bozkurt, S. Kribbs, F. Clubb, L. Michael, V. Didenko, P. Hornsby, Y. Seta, H. Oral, F. Spinale, D. Mann   +9 more
semanticscholar   +1 more source