Results 31 to 40 of about 34,617,262 (326)

The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-alpha [PDF]

, 2002
Heparin-binding epidermal growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is implicated in a variety of biological processes, including reproduction.
Mardon, Helen J., Yoo, Hyung-J, Katya Chobotova, Barlow, David, Helen J. Mardon, Carver, J, Chobotova, K, Muchmore, ME, William J. Gullick, Muchmore, Mary-Elizabeth, Chobotova, Katya, Janet Carver, Yoo, HJ, Hyung-J Yoo, David H. Barlow, Manek, Sanjiv, Sanjiv Manek, Manek, S, Barlow, DH, Mary-Elizabeth Muchmore, Gullick, WJ, Gullick, William J., Carver, Janet, Mardon, HJ   +23 more
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Tumor necrosis factor alpha improves glucose homeostasis in diabetic mice independent with tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2

Endocrine Journal, 2018
Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes.
Wu, Shanshan, Dong, Kai, Wang, Jiajia, Bi, Yaxin   +3 more
openaire   +3 more sources

The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis [PDF]

, 2012
Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial ...
Ricardo F. Antunes, Dumitriu, Ingrid E; id_orcid, Kaski, JC, Antunes, Ricardo F, Juan Carlos Kaski, Kaski, Juan Carlos, Dumitriu, IE, Ingrid E. Dumitriu, Antunes, RF   +8 more
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Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications

Frontiers in Immunology, 2018
Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 is ubiquitously expressed on almost all cells, while TNFR2 exhibits a limited ...
Sujuan Yang, Sujuan Yang, Julie Wang, David Douglass Brand, Song Guo Zheng   +4 more
doaj   +1 more source

Role of Tumor Necrosis Factor Alpha inHelicobacter pyloriGastritis in Tumor Necrosis Factor Receptor 1-Deficient Mice [PDF]

Infection and Immunity, 2002
ABSTRACTIncreased gastric production of interleukin 8 and tumor necrosis factor alpha (TNF-α) has been implicated in the pathogenesis ofHelicobacter pylori-associated gastroduodenal disease. In the present study we used a mouse model to demonstrate whether loss of the tumor necrosis factor receptor 1 (TNF-R1) function leads to differences in gastric ...
Ulrike, Thalmaier, Norbert, Lehn, Klaus, Pfeffer, Manfred, Stolte, Michael, Vieth, Wulf, Schneider-Brachert   +5 more
openaire   +2 more sources

Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. [PDF]

, 2013
The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine playing a key role in tissue regeneration and remodeling.
Jens Niewoehner, Monika Baehner, Kohnert, Ulrich, Schraeml, Michael, Ulrich Kohnert, Alfred Lammens, Katja Lammens, Lammens, Katja, Karl-Peter Hopfner, Leopold von Proff, Lammens, Alfred, Hopfner, Karl-Peter, Niewoehner, Jens, Michael Schraeml, Baehner, Monika, Proff, Leopold von   +15 more
core   +2 more sources

Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma

Tumor Biology, 2017
Tumor necrosis factor receptor–associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor
Tian-Fu Wu, Yi-Cun Li, Si-Rui Ma, Bing-Liu, Wen-Feng Zhang, Zhi-Jun Sun   +5 more
doaj   +1 more source

Locally up-regulated lymphotoxin a, not systemic tumor necrosis factor a, is the principle mediator of murine cerebral malaria [PDF]

, 2002
Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-{alpha} has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin {alpha} (LT{alpha}) in CM has been overlooked.
Sanjeet Sawhney, Mynott, T.L., Kaye, PM, De Souza, J Brian, Bickle, Quentin D, Kaye, P.M., Engwerda, C.R., Sawhney, Sanjeet, Engwerda, CR, Tracey L. Mynott, Paul M. Kaye, Christian R. Engwerda, Bickle, Q.D., Sawhney, S, Bickle, QD, Mynott, Tracey L, De Souza, JB, Mynott, TL, Engwerda, Christian R, Sawhney, S., J. Brian De Souza, Quentin D. Bickle, Kaye, Paul M, De Souza, J.B.   +23 more
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Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34 -> q36 by fluorescence in situ hybridization and radiation hybrid mapping [PDF]

, 2005
We have cloned the complete coding region of the porcine TNFSF10 gene. The porcine TNFSF10 cDNA has an ORF of 870 nucleotides and shares 85 % identity with human TNFSF10, and 75% and 72% identity with rat and mouse Tnfsf10 coding sequences, respectively.
Kemter, E., Kemter, E, Leeb, T., Kuiper, H., Klose, R., Boelhauve, M., Kuiper, H, Philipp, U., Philipp, U, Wolf, E, Distl, O., Wolf, E., Klose, R, Leeb, Tosso, Distl, O, Boelhauve, M   +15 more
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Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α [PDF]

, 2013
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B ...
Unlu, Sebnem, Gillian M. Tannahill (440532), O’Neill Luke A., Kent Z. Q. Wang (440530), Kent Z. Q. Wang, Galson, Deborah L., Galson Deborah L., Luke A. O’Neill (440534), Tannahill Gillian M., Auron Philip E., O'Neill, LA, Adamik, Juraj, Su An-Jey A., Gillian M. Tannahill, Sebnem Unlu, Philip E. Auron, Unlu Sebnem, Gillian M Tannahill, Adamik, J, An-Jey A. Su, Yan, Chunhong, Auron, PE, Deborah L. Galson, Luke A. O’Neill, Luke A O'Neill, O’Neill, Luke A., Su, AJA, Tannahill, GM, An-Jey A. Su (440531), O\u27Neill, Luke A., Deborah L Galson, Wang, KZQ, An-Jey A Su, Kent Z Q Wang, Unlu, S, Sebnem Unlu (156119), Wang, Kent Z. Q., Juraj Adamik (440529), Galson, DL, Adamik Juraj, Philip E. Auron (440535), Philip E Auron, Wang Kent Z. Q., Su, An Jey A., Tannahill, Gillian M., Su, An-Jey A., Wang, Kent Z.Q., Deborah L. Galson (440533), Auron, Philip E., Juraj Adamik   +49 more
core   +1 more source