Novel Cyclic Peptides Inhibiting Tumor Necrosis Factor Receptor 1 Activity. [PDF]
ACS Medicinal Chemistry LettersThis patent application pertains to macrocyclic peptides, generally represented by Formula I. These compounds exhibit selective binding to tumor necrosis factor receptor 1 (TNFR1) and hold the potential for mitigating the progression of diseases or ...
Qi-Long Hu, Steven H. Liang
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Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies [PDF]
Frontiers in Immunology, 2018 Progranulin (PGRN) is a secreted anti-inflammatory protein which can be processed by neutrophil proteases to various granulins. It has been reported that at least a significant portion of the anti-inflammatory effects of PGRN is due to direct high ...
Isabell Lang +2 more
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Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice [PDF]
International Journal of COPD, 2016 Masaki Fujita,1 Hiroshi Ouchi,2 Satoshi Ikegame,2 Eiji Harada,2 Takemasa Matsumoto,1 Junji Uchino,1 Yoichi Nakanishi,2 Kentaro Watanabe1 1Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, 2Research Institute for Diseases of ...
Fujita M +7 more
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Tumor Necrosis Factor Induces Tumor Necrosis via Tumor Necrosis Factor Receptor Type 1-Expressing Endothelial Cells of the Tumor Vasculature [PDF]
The American Journal of Pathology, 2000 Activation of endothelial cells, fibrin deposition, and coagulation within the tumor vasculature has been shown in vivo to correlate with the occurrence of tumor necrosis factor (TNF)-induced tumor necrosis in mice. In the present study we investigated which target cells mediate the TNF-induced necrosis in fibrosarcomas grown in wild type (wt), TNF ...
B, Stoelcker +5 more
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Depressed female smokers have higher levels of soluble tumor necrosis factor receptor 1 [PDF]
Addictive Behaviors Reports, 2018 Aim: To examine clinical and biomarkers in depressed female smokers, in order to better clarify the process that link mood disorders, childhood trauma and smoking in women. Methods: The clinical sample comprised women with unipolar or bipolar depression,
Mauro Porcu +6 more
doaj +2 more sources
Alantolactone Activates the Extracellular Signal-Regulated Kinase Signaling Pathway to Promote Tumor Necrosis Factor Receptor 1 Ectodomain Shedding [PDF]
MoleculesAlantolactone is a sesquiterpene lactone that possesses anticancer and anti-inflammatory properties. We previously demonstrated that several sesquiterpenes, including alantolactone, induced the ectodomain shedding of tumor necrosis factor receptor 1 (TNF-
Piimwara Yarangsee +3 more
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Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome [PDF]
Definitions, 2020 semanticscholar +5 more sources
Association Study of Tumor Necrosis Factor Receptor 1 (TNFR1) Gene Polymorphisms with Schizophrenia in the Polish Population [PDF]
Mediators of Inflammation, 2017 Schizophrenia is a devastating mental disorder with undetermined aetiology. Previous research has suggested that dysregulation of proinflammatory cytokines and their receptors plays a role in developing schizophrenia.
Renata Suchanek-Raif +6 more
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Tumor Necrosis Factor Receptor 1 Measurement [PDF]
Definitions, 2020 semanticscholar +2 more sources
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. [PDF]
Proceedings of the National Academy of Sciences, 1996 The two cell surface receptors for tumor necrosis factor (TNF) interact with a number of intracellular signal transducing proteins. The association of TRADD, a 34-kDa cytoplasmic protein containing a C-terminal death domain, with aggregated TNF receptor 1 (TNF-R1) through their respective death domains leads to NF-κB activation and programmed cell ...
H. Shu, M. Takeuchi, D. Goeddel
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