Results 21 to 30 of about 34,617,262 (326)

Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-α Antagonist* [PDF]

Journal of Biological Chemistry, 2008
Tumor necrosis factor-α (TNF) induces inflammatory response predominantly through the TNF receptor-1 (TNFR1). Thus, blocking the binding of TNF to TNFR1 is an important strategy for the treatment of many inflammatory diseases, such as hepatitis and ...
H. Shibata, Y. Yoshioka, A. Ohkawa, Kyoko Minowa, Y. Mukai, Y. Abe, M. Taniai, T. Nomura, H. Kayamuro, H. Nabeshi, T. Sugita, S. Imai, K. Nagano, T. Yoshikawa, T. Fujita, S. Nakagawa, A. Yamamoto, T. Ohta, T. Hayakawa, T. Mayumi, P. Vandenabeele, B. Aggarwal, Teruya Nakamura, Y. Yamagata, S. Tsunoda, H. Kamada, Y. Tsutsumi   +26 more
semanticscholar   +3 more sources

Behavior of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptor 1/Tumor Necrosis Factor Receptor 2 System in Mononuclear Cells Recovered From Peritoneal Fluid of Women With Endometriosis at Different Stages [PDF]

Reproductive Sciences, 2015
During endometriosis, a breakdown occurs in endometrial and peritoneal homeostasis caused by cytokine-induced cell proliferation and dysregulation of apoptosis. We studied tumor necrosis factor (TNF)-α, TNF receptor (TNFR) 1, and TNFR2 gene expression at both messenger RNA (mRNA) and protein levels in peritoneal fluid (PF) mononuclear cells (PFMCs ...
F. M. Salmeri, A. Laganà, V. Sofo, O. Triolo, E. Sturlese, G. Retto, A. Pizzo, A. D'Ascola, Salvatore Campo   +8 more
semanticscholar   +4 more sources

Role of the Interaction of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors 1 and 2 in Bone-Related Cells [PDF]

International Journal of Molecular Sciences, 2022
Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine expressed by macrophages, monocytes, and T cells, and its expression is triggered by the immune system in response to pathogens and their products, such as endotoxins. TNF-α plays an important role in host defense by inducing inflammatory reactions such as phagocytes and cytocidal systems ...
Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi   +9 more
openaire   +2 more sources

Casein Kinase-1 Phosphorylates the p75 Tumor Necrosis Factor Receptor and Negatively Regulates Tumor Necrosis Factor Signaling for Apoptosis [PDF]

Journal of Biological Chemistry, 1995
Cellular responses initiated by tumor necrosis factor (TNF) are mediated by two different cell surface receptors with respective molecular masses of 55 kDa (p55) and 75 kDa (p75). p55 is functional in almost every cell type and can independently transmit most biological activities of TNF.
Beyaert, R., Vanhaesebroeck, B., Declercq, W., Van Lint, Johan, Vandenabele, P., Agostinis, Patrizia, Vandenheede, Jackie, Fiers, W.   +7 more
openaire   +2 more sources

The relationship between TRAF6 and tumors

Cancer Cell International, 2020
Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily.
Jiaoduan Li, Nian Liu, Ling Tang, Bei Yan, Xiang Chen, Jianglin Zhang, Cong Peng   +6 more
doaj   +1 more source

S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts.

PLoS ONE, 2023
Periodontal disease is the most common dental health problem characterized by the destruction of connective tissue and the resorption of alveolar bone resulting from a chronic infection associated with pathogenic bacteria in the gingiva.
Hiroshi Nango, Masahiro Ohtani
doaj   +1 more source

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor [PDF]

Proceedings of the National Academy of Sciences, 1998
Tumor necrosis factor (TNF) can induce a variety of cellular responses at low picomolar concentrations. This is in apparent conflict with the published dissociation constants for TNF binding to TNF receptors in the order of 100–500 pM. To elucidate the mechanisms underlying the outstanding cellular sensitivity to TNF, we determined
M, Grell, H, Wajant, G, Zimmermann, P, Scheurich   +3 more
openaire   +2 more sources

Cell Fate Decisions Regulated by K63 Ubiquitination of Tumor Necrosis Factor Receptor 1 [PDF]

Mol Cell Biol, 2014
J. Fritsch, M. Stephan, V. Tchikov, S. Winoto-morbach, S. Gubkina, D. Kabelitz, S. Schütze   +6 more
semanticscholar   +2 more sources

Tumor necrosis factor receptor 1 functions as a tumor suppressor

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2012
Tumor necrosis factor (TNF) is a key player in inflammatory bowel disease and has been variably associated with carcinogenesis, but details of the cross talk between inflammatory and tumorigenic pathways remain incompletely understood. It has been shown that, in C57BL/6 mice, signaling via TNF receptor 1 (TNFR1) is protective from injury and ...
Fengqi, Chang, Michelle R, Lacey, Mostafa, Bouljihad, Kerstin, Höner Zu Bentrup, Ilana S, Fortgang   +4 more
openaire   +3 more sources

Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein

Definitions, 2020
Tumor necrosis factor receptor type 1-associated DEATH domain protein (312 aa, ~34 kDa) is encoded by the human TRADD gene. This protein plays a role in apoptosis and the activation of NF-kappa-B signaling pathways.

semanticscholar   +1 more source