Results 91 to 100 of about 3,117,179 (310)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
RNA-binding proteins in tumor progression
Journal of Hematology & Oncology, 2020 RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA ...
Hai Qin +6 more
doaj +1 more source
UVRAG Promotes Tumor Progression through Regulating SP1 in Colorectal Cancer
, 2023 Colorectal cancer (CRC) is the third most common type of cancer. The ultraviolet radiation resistance-associated gene (UVRAG) plays a role in autophagy and has been implicated in tumor progression and prognosis.
Nan Chen +6 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
BMC NursingObjectives Childhood obesity prevention is a public health priority to reduce the burden of chronic diseases. This study assessed the impact of a capacity-building program designed to enhance school nurses’ competencies in adolescent obesity prevention ...
Radhia Chaieb +6 more
doaj +1 more source
Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]
, 2013 Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core
Tumor-stroma derived gene expression patterns as prognosticators in breast cancer [PDF]
, 2010 The stroma, which embeds epithelial cells, plays a major role in the shaping and physiological regulation of animal organs such as the breast. Aberrant functioning of the stroma was found to support tumorigenesis and cancer progression.
Rajski, Michal
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
. Modern concepts on carcinogenesis: the value of insufficiency of malignant cell elimination mechanisms in the tumor progression in case of neoplasia at different localizations [PDF]
Саратовский научно-медицинский журнал, 2016 The article presents the review of contemporary concepts of tumor induction mechanisms applicable for neoplastic transformation, promotion and proliferation.
Chesnokova N.P. +4 more
doaj
The role of NCAM signaling and its effector protein, [beta]1-integrin, in tumor progression [PDF]
, 2007 Neural Cell Adhesion Molecule (NCAM) is a member of the large family of Ca2+independent, immunoglobulin (Ig)-like cell adhesion molecules. So far, its function in homophilic and heterophilic interactions has been mainly studied in neuronal cells, where ...
Kren, Angelika
core +1 more source