Results 121 to 130 of about 3,117,179 (310)

Feasibility of multiomics tumor profiling for guiding treatment of melanoma

There is limited evidence supporting the feasibility of using omics and functional technologies to inform treatment decisions. Here we present results from a cohort of 116 melanoma patients in the prospective, multicentric observational Tumor Profiler ...
Frei, Anja, Irmisch, Anja, Baciu-Drăgan, Monica-Andreea, Ring, Alexander, Tusup, Marina, Schuerch, Manuel, Beisel, Christian, Lehmann, Kjong-Van, Gosztonyi, Benedict, Rätsch, Gunnar, Chicherova, Natalia, Bertolini, Anne, Heinzelmann, Viola, Theocharides, Alexandre, Rahimzadeh, Parisa, Bonilla, Ximena, Chevrier, Stéphane, Pelkmans, Lucas, Maass, Gerd, Lischetti, Ulrike, Dummer, Reinhard, Sivapatham, Sujana, Wicki, Andreas, Boos, Laura Amanda, Mena, Julien, Gut, Gabriele, Wollscheid, Bernd, Nowak, Marta, Toussaint, Nora Christina, Milani, Emanuela S., del Castillo, Jacobo Sarabia, Beerenwinkel, Niko, Prummer, Michael, Snijder, Berend, Goetze, Sandra, Moch, Holger, Ferreira, Pedro, Sobottka, Bettina, Casanova, Ruben, Jacobs, Alice K., Koelzer, Viktor H., Kuipers, Jack, Bacac, Marina, Miglino, Nicola, Jacob, Francis, Aebersold, Ruedi, Weller, Michael, Wegmann, Rebekka, Manz, Markus G., Mehra, Tarun, Esposito, Cinzia, Bodenmiller, Bernd, Singer, Franziska, Levesque, Mitchell P., Yu, Shuqing   +54 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. [PDF]

, 2012
Krüppel-like factor 8 (KLF8) has only recently been identified to be involved in tumor cell proliferation and invasion of several different tumor entities like renal cell carcinoma, hepatocellular carcinoma and breast cancer.
Schnell, Oliver, Kretzschmar Hans, Juerchott Kathrin, Eigenbrod, Sabina, Valerie Albrecht, Romagna, Alexander, Juerchott, Kathrin, Irene Jaehnert, Jörg-Christian Tonn, Eigenbrod Sabina, Hans Kretzschmar, Jaehnert, Irene, Sabina Eigenbrod (187226), Hans Kretzschmar (187242), Kretzschmar, Hans, Schichor Christian, Romagna, A., Albrecht, Valerie, Christian Schichor, Alexander Romagna, Schnell, O., Juerchott, K., Tonn, Jörg-Christian, Irene Jaehnert (187215), Albrecht, V., Schichor, C., Romagna Alexander, Valerie Albrecht (187218), Eigenbrod, S., Kathrin Juerchott (187233), Christian Schichor (187256), Schichor, Christian, Jörg-Christian Tonn (187250), Albrecht Valerie, Jaehnert, I., Kathrin Juerchott, Kretzschmar, H., Alexander Romagna (187206), Oliver Schnell (187202), Jaehnert Irene, Sabina Eigenbrod, Schnell Oliver, Tonn Jörg-Christian, Tonn, J., Oliver Schnell   +44 more
core   +2 more sources

The disruption of hematopoiesis in tumor progression

Blood Science, 2019
Abstract Human adult hematopoiesis maintains homeostasis by replacing depleted progeny pools and inducing a primary immune response to infectious diseases and tumors. Recent studies have shown that tumor progression is associated with profound perturbations in hematopoiesis.
Xiaofang Wang, Yangqiu Li
openaire   +3 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Metabolic Alterations in Pancreatic Cancer Progression [PDF]

, 2019
Pancreatic cancer is the third leading cause of cancer-related deaths in the USA. Pancreatic tumors are characterized by enhanced glycolytic metabolism promoted by a hypoxic tumor microenvironment and a resultant acidic milieu.
Dasgupta, Aneesha, Abrego, Jaime, Surendra K. Shukla, Rai, Vikrant, Illies, Alysha, Buettner, Kyla, Swanson, Benjamin J., Jaime Abrego, Alysha Illies, Aneesha Dasgupta, Nina Chaika, Enza Vernucci, Audrey J. Lazenby, Gunda, Venugopal, Lazenby, Audrey J., Singh, Pankaj K., Shukla, Surendra K., Vikrant Rai, Benjamin J. Swanson, Vernucci, Enza, Kyla Buettner, Venugopal Gunda, Chaika, Nina V., Yu, Fang, Fang Yu, Pankaj K. Singh   +25 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression

The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays a crucial role in driving tumor progression, shaping treatment responses, and influencing metastasis.
Bogdan-Alexandru Gheban, Alexandra Buruiană, Doința Crișan, Ioana-Andreea Gheban-Roșca, Carmen Georgiu, Maria Crișan   +5 more
core   +1 more source