Results 221 to 230 of about 1,149,461 (264)

“Stromatogenesis” and Tumor Progression

International Journal of Surgical Pathology, 2004
“Stromatogenesis” is the formation of new stroma occurring, in parallel with the neoplastic process, at sites of active tumor invasion, i.e., at the free surface of a developing exophytic tumor, at the invading tumor front of an advancing endophytic tumor, and at sites of tumor metastasis, wherein the newly formed stroma disrupts the continuity of ...
Efthimios, Sivridis, Alexandra, Giatromanolaki, Michael I, Koukourakis   +2 more
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Aspects of tumor progression

Medical Hypotheses, 2020
A model is introduced here that for the first time describes carcinogenesis in the context of and interacting with associated inflammatory processes. Central to the model are the control of cytokine production by the innate immune system and its disturbance by additional uncontrolled cytokine sources.
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Differentiation and Tumor Progression

1995
Clinical and experimental experience indicate that differentiation and malignancy are inversely correlated. However, more recent experimental studies using mouse and human keratinocyte systems have demonstrated that complete or even substantial loss in overall epithelial differentiation is not a prerequisite for malignant growth of cancer cells.
N E, Fusenig, D, Breitkreutz, P, Boukamp, P, Tomakidi, H J, Stark   +4 more
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Tumor Progression and Homeostasis

1976
Publisher Summary The idea that cancer evolves as a series of sequential heritable cellular changes is quite old. It probably had its genesis in the common clinical observation that human neoplasia often appears to undergo change during its clinical course, such that what was originally a relatively benign tumor of low grade is transformed over a ...
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Tumor associated macrophages and neutrophils in tumor progression

Journal of Cellular Physiology, 2013
AbstractTumor‐associated macrophages (TAMs) are a key component of the tumor microenvironment and orchestrate various aspects of cancer. Diversity and plasticity are hallmarks of cells of the monocyte–macrophage lineage. In response to distinct signals macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a ...
GALDIERO, MARIA ROSARIA, Garlanda C., Jaillon S., MARONE, GIANNI, Mantovani A.   +4 more
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Molecular Mechanisms of Tumor Angiogenesis and Tumor Progression

Journal of Neuro-Oncology, 2000
The formation of new blood vessels (angiogenesis) is crucial for the growth and persistence of primary solid tumors and their metastases. Furthermore, angiogenesis is also required for metastatic dissemination, since an increase in vascular density will allow easier access of tumor cells to the circulation.
U, Cavallaro, G, Christofori
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Angiogenesis and Tumor Progression in Neuroendocrine Digestive Tumors

Journal of Surgical Research, 2009
Clinical observations suggest that in neuroendocrine digestive tumors a high intratumoral microvascular density is associated with good prognosis. We used an experimental orthotopic xenograft model to analyze the relations between angiogenic activity and tumor progression in this tumor subset.We compared 2 endocrine cell lines: STC-1, a low vascular ...
Poncet, Gilles, Villaume, Karine, Walter, Thomas, Pourreyron, Céline, Theillaumas, Aurélie, Lépinasse, Florian, Hervieu, Valérie, Cordier-Bussat, Martine, Scoazec, Jean-Yves, Roche, Colette   +9 more
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Chromosomes and Tumor Progression

1980
Chromosome studies suggest that most neoplasms are unicellular in origin (i.e., "clones"), and that biological progression, typically associated with loss of "differentiated" properties, results from acquired genetic instability in the neoplastic population leading to sequential appearance of increasingly mutant subpopulations with greater selective ...
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Neurotrophin receptors, tumor progression and tumor maturation

Molecular Medicine Today, 1996
The nerve growth factor receptor TrkA was initially isolated as a transforming oncogene, trk, in which most of the extracellular receptor part is replaced by the coding sequence for a tropomyosin-encoding gene. The impact that the identification of the first neurotrophin receptor has made on the entire field of developmental neurobiology cannot be ...
S, Påhlman, J C, Hoehner
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Diversification and progression of malignant tumors

BioEssays, 1987
AbstractTumor‐cell diversification mechanisms insure that malignant neoplasms contain diversified tumor‐cell subpopulations. Because of the instability of tumor cell phenotypes, some malignant cells will evolve with the most favorable properties for their progression to highly metastatic cells.
G L, Nicolson, N L, Rosenberg
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