Results 271 to 280 of about 3,117,179 (310)

Tumor Progression and Homeostasis

1976
Publisher Summary The idea that cancer evolves as a series of sequential heritable cellular changes is quite old. It probably had its genesis in the common clinical observation that human neoplasia often appears to undergo change during its clinical course, such that what was originally a relatively benign tumor of low grade is transformed over a ...
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Chromosomes and Tumor Progression

1980
Chromosome studies suggest that most neoplasms are unicellular in origin (i.e., "clones"), and that biological progression, typically associated with loss of "differentiated" properties, results from acquired genetic instability in the neoplastic population leading to sequential appearance of increasingly mutant subpopulations with greater selective ...
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Tumor associated macrophages and neutrophils in tumor progression

Journal of Cellular Physiology, 2013
AbstractTumor‐associated macrophages (TAMs) are a key component of the tumor microenvironment and orchestrate various aspects of cancer. Diversity and plasticity are hallmarks of cells of the monocyte–macrophage lineage. In response to distinct signals macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a ...
GALDIERO, MARIA ROSARIA, Garlanda C., Jaillon S., MARONE, GIANNI, Mantovani A.   +4 more
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Molecular Mechanisms of Tumor Angiogenesis and Tumor Progression

Journal of Neuro-Oncology, 2000
The formation of new blood vessels (angiogenesis) is crucial for the growth and persistence of primary solid tumors and their metastases. Furthermore, angiogenesis is also required for metastatic dissemination, since an increase in vascular density will allow easier access of tumor cells to the circulation.
U, Cavallaro, G, Christofori
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Neurotrophin receptors, tumor progression and tumor maturation

Molecular Medicine Today, 1996
The nerve growth factor receptor TrkA was initially isolated as a transforming oncogene, trk, in which most of the extracellular receptor part is replaced by the coding sequence for a tropomyosin-encoding gene. The impact that the identification of the first neurotrophin receptor has made on the entire field of developmental neurobiology cannot be ...
S, Påhlman, J C, Hoehner
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Angiogenesis and Tumor Progression in Neuroendocrine Digestive Tumors

Journal of Surgical Research, 2009
Clinical observations suggest that in neuroendocrine digestive tumors a high intratumoral microvascular density is associated with good prognosis. We used an experimental orthotopic xenograft model to analyze the relations between angiogenic activity and tumor progression in this tumor subset.We compared 2 endocrine cell lines: STC-1, a low vascular ...
Poncet, Gilles, Villaume, Karine, Walter, Thomas, Pourreyron, Céline, Theillaumas, Aurélie, Lépinasse, Florian, Hervieu, Valérie, Cordier-Bussat, Martine, Scoazec, Jean-Yves, Roche, Colette   +9 more
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Diversification and progression of malignant tumors

BioEssays, 1987
AbstractTumor‐cell diversification mechanisms insure that malignant neoplasms contain diversified tumor‐cell subpopulations. Because of the instability of tumor cell phenotypes, some malignant cells will evolve with the most favorable properties for their progression to highly metastatic cells.
G L, Nicolson, N L, Rosenberg
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Tumor Progression and Catastrophe Theory

1993
Progression is the development from bad to worse that is often observed in tumors. It can follow different courses, not only in different organs, but also in the same organ: sometimes there is a smooth, continuous progression from normal to malignant cells, sometimes suddenly a highly malignant tumor arises.
Daams, H., Cortassa, S., Aon, M.A., Westerhoff, H.V.   +3 more
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HDAC6: Tumor Progression and Beyond

Current Cancer Drug Targets
Histone Deacetylase 6 (HDAC6) is an intriguing therapeutic target in cancer research, distinguished as the only HDAC family member predominantly located in the cytoplasm. HDAC6 features two catalytic domains and a unique ubiquitin-binding domain, which sets it apart from other HDACs.
Joao Marcos Oliveira-Silva, Leilane Sales de Oliveira, Joao Vitor Marangoni Taglieri, Lais Bernardo Lopes, Carlos Vinicius Expedito de Souza, Hanna Karolina de Araujo Batistao, Angel Mauricio Castro-Gamero   +6 more
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Brain and other central nervous system tumor statistics, 2021

Ca-A Cancer Journal for Clinicians, 2021
Rebecca L. Siegel, Jill S. Barnholtz-Sloan, Carol Kruchko   +2 more
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