Results 51 to 60 of about 5,576,002 (348)
Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Journal of Hematology & Oncology, 2022 Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids.
Mahshid Deldar Abad Paskeh +18 more
semanticscholar +1 more source
Journal of Hematology & Oncology, 2019 Background Cell-cell interactions maintain tissue homeostasis and contribute to dynamic alteration of the tumor microenvironment (TME). Communication between cancer and host cells not only promotes advanced disease aggression but also determines ...
Wei-Lun Hwang +4 more
doaj +1 more source
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages [PDF]
, 2007 Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)‐induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy.
Barleon +47 more
core +1 more source
Monitoring Radiographic Brain Tumor Progression
Toxins, 2011 Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV) through its inherent heterogeneous enhancement, growth patterns, and ...
John H. Sampson +4 more
doaj +1 more source
Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies
Experimental Hematology & Oncology, 2021 Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity
Shangli Zhu +4 more
doaj +1 more source
ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth [PDF]
, 2017 Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the actomyosin regulatory ROCK1 and ROCK2 kinases increased with tumor progression in human and ...
Anderson, Kurt I. +12 more
core +1 more source
Tumor progression and metastasis [PDF]
Carcinogenesis, 2000 It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsible for the acquisition of ...
openaire +2 more sources
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core +1 more source
TIMER2.0 for analysis of tumor-infiltrating immune cells
Nucleic Acids Res., 2020 Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment.
Taiwen Li +7 more
semanticscholar +1 more source
Selinexor overcomes hypoxia-induced drug resistance in multiple myeloma [PDF]
, 2017 Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Azab, Abdel Kareem +4 more
core +3 more sources