Results 181 to 190 of about 1,355,842 (299)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Cancer-Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities. [PDF]

Adv Sci (Weinh)
Liu R, Su L, Gao S, Liu W, Wang H.
europepmc   +1 more source

Immune‐Related Prognostic Gene Identification in Lung Squamous Cell Carcinoma With the Cancer Genome Atlas Mining and Immunohistochemistry Validation

iNew Medicine, EarlyView.
ABSTRACT Objective In the cancer microenvironment, stromal and immune cells hold clinical importance. In lung squamous cell carcinoma (LSCC), the aim of this study was to find immune‐linked gene expression that has prognostic pertinence. Methods From the Cancer Genome Atlas, this study obtained the LSCC gene expression profile.
Weijia Jiang, Jing Xu, Wenwen Ma, Qingjie Zhu, Pawin Pongkorpsakol, Guoping Sun   +5 more
wiley   +1 more source

Screening anticancer peptides performance in organotypic prostate tumor-stroma 3D models. [PDF]

Int J Cancer
Matos B, Monteiro MV, Lagarto MR, Howl J, Jerónimo C, Gaspar VM, Mano JF, Fardilha M.   +7 more
europepmc   +1 more source

Transperineal Ultrasound in Chronic Pelvic Pain: A Systematic Review

Journal of Clinical Ultrasound, EarlyView.
Graphical abstract illustrating the systematic review process and highlighting key pelvic floor musculature (PFM) alterations detected by transperineal ultrasound (TPU) in patients with chronic pelvic pain (CPP) and associated conditions. These findings provide insights to enhance understanding and management of CPP.
Giulia Paoni Saccone, Noemi Tonti, Valeria Gangale, Maria Grazia Porpora, Federica Tomao, Violante Di Donato, Innocenza Palaia, Giusi Santangelo, Ludovico Muzii, Giuseppe Rizzo, Giorgia Perniola   +10 more
wiley   +1 more source

Combining tertiary lymphoid structures and tumor stroma percentage for predicting prognosis and chemotherapy benefits in stage II-III colorectal cancer. [PDF]

BMC Cancer
Yang K, Li H, Dong X, Lin J, Li Z, Jiang W, Yan J.   +6 more
europepmc   +1 more source

A two‐stage model for precise identification and Gleason grading of clinically significant prostate cancer: a hybrid approach

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 93-105, March 2025.
This study developed a two‐stage model using radiomics‐based multiparametric MRI and clinical indicators to help identify and grade clinically significant prostate cancer. The model showed promising levels of diagnostic accuracy and predictive performance.
Yuyan Zou, Xuechun Wang, Fen Ma, Xulun Liu, Chunyue Jiao, Zhen Kang, Jingjing Cui, Yang Zhang, Yan Xie, Lei Chen, Ronghua Tian   +10 more
wiley   +1 more source

Automating tumor-stroma ratio quantification in colon cancer patients from the UNITED study. [PDF]

ESMO Open
Heilijgers F, Polack M, Roodvoets AGH, Meershoek-Klein Kranenbarg E, Peeters KCMJ, Buettner R, Tolkach Y, Mesker WE, UNITED Collaboration.   +8 more
europepmc   +1 more source

Pigmented Fibroepithelioma of Pinkus in Pregnancy: Strengths and Limitations of Reflectance Confocal Microscopy, Line‐Field Optical Coherence Tomography and Line‐Field Optical Coherence Tomography Artificial Intelligence Tool

JEADV Clinical Practice, EarlyView.
ABSTRACT Pigmented fibroepithelioma of Pinkus (FeP), a rare fibroepithelial variant of basal cell carcinoma (BCC), is clinically and dermoscopically challenging to diagnose and may mimic melanoma as well as benign lesions, such as sebhorreic keratosis.
Lucia Finistauri Guacci, Raimondo Rossi, Francesca Svara, Andrea Ascione, Giulio Bortone, Alessia Scipione, Steven Paul Nisticò, Giovanni Pellacani, Flavia Persechino   +8 more
wiley   +1 more source

Structure-functionality relationship of collagen-fibrin interpenetrating hydrogels for engineered tumor-stroma models. [PDF]

Acta Biomater
Choi SR, Mellican SM, Roberts TJ, Kang S, Elzey BD, Kong H, Davis CS, Fishel ML, Flick MJ, Wolberg AS, Han B.   +10 more
europepmc   +1 more source