Results 61 to 70 of about 481,131 (293)
Mutant p53 and ETS2, a tale of reciprocity
Frontiers in Oncology, 2016 TP53 is one of the most frequently inactivated tumor suppressor genes in human cancer. However, unlike other tumor suppressor genes whose expression is lost, TP53 is usually inactivated as a result of a single nucleotide change within the coding region.
Luis Alfonso Martinez
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Cancer: Disease Caused by Alteration of Genes [PDF]
International Journal of Basic Science in Medicine, 2016 In normal cells when genetic defects occur, there are some sensitive mechanisms through which the defect might be repaired or apoptosis might be induced.
Manzoor Ahmad Malik +2 more
doaj +1 more source
, 1995 Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut +1 more
core +1 more source
Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]
, 2013 Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op +4 more
core +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Journal of Pharmaceutical AnalysisCancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.
Xuejiao Leng +11 more
doaj +1 more source
Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study. [PDF]
PLoS ONE, 2016 Mitochondrial genes play important roles in cellular energy metabolism, free radical generation, and apoptosis. Dysregulation of these genes have long been suspected to contribute to the generation of reactive oxygen species (ROS), increased ...
Ishrat Mahjabeen, Mahmood Akhtar Kayani
doaj +1 more source
The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. [PDF]
, 2019 TSPX is a tumor suppressor gene located at Xp11.22, a prostate cancer susceptibility locus. It is ubiquitously expressed in most tissues but frequently downregulated in various cancers, including lung, brain, liver and prostate cancers.
Chris Lau, Yun-Fai +4 more
core +1 more source
MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency [PDF]
, 2016 open9siopenFong, Louise Y.; Taccioli, Cristian; Jing, Ruiyan; Smalley, Karl J.; Alder, Hansjuerg; Jiang, Yubao; Fadda, Paolo; Farber, John L.; Croce, Carlo M.Fong, Louise Y.; Taccioli, Cristian; Jing, Ruiyan; Smalley, Karl J.; Alder, Hansjuerg; Jiang ...
Alder, Hansjuerg +8 more
core +2 more sources