Results 171 to 180 of about 304,620 (215)
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The retinoblastoma tumor suppressor protein
Current Opinion in Genetics & Development, 1995Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/
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Activation of the p53 tumor suppressor protein
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002The p53 tumor suppressor gene plays an important role in preventing cancer development, by arresting or killing potential tumor cells. Mutations within the p53 gene, leading to the loss of p53 activity, are found in about half of all human cancers, while many of the tumors that retain wild type p53 carry mutations in the pathways that allow full ...
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Cytoskeletal and adhesion proteins as tumor suppressors
Current Opinion in Cell Biology, 1997In the past year, significant progress has been made in the attempt to understand the molecular mechanisms underlying signaling that is induced by cell-cell and cell-extracellular-matrix adhesion and that involves the cytoskeleton. In particular, molecules of the cytoplasmic plaques of cell-cell junctions have been shown to complex with transcription ...
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Protein Partners of the BRCA1 Tumor Suppressor
Breast Disease, 1998The primary amino acid sequence of BRCA1 offers few clues about the mechanism by which it suppresses tumor formation in normal breast and ovarian tissues. In an effort to unravel its biological functions, investigators have sought to identify the proteins that interact with BRCA1 in vivo.
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Regulation and function of the p53 tumor suppressor protein
Current Opinion in Cell Biology, 2001Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
K M, Ryan, A C, Phillips, K H, Vousden
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2001
The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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New roles for the RB tumor suppressor protein
Current Opinion in Genetics & Development, 2004For a gene whose existence was first postulated in 1971, was cloned in 1986 and whose functions have been extensively characterized ever since, you might be inclined to think there was not much new to report regarding the retinoblastoma tumor suppressor gene (RB)--but you would be wrong to make such an assumption.
Huiping, Liu +4 more
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The von Hippel–Lindau tumor suppressor protein
Current Opinion in Genetics & Development, 2001The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen.
M, Ivan, W G, Kaelin
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Expression of the APC tumor suppressor protein in oligodendroglia
Glia, 1996Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene have been linked to familial polyposis, an inherited predisposition to colon cancer, and a high percentage of sporadic colon adenomas. Although this gene is best known for its role in development of bowel neoplasms, in recent studies we have found that APC mRNA levels are greatly ...
R V, Bhat +7 more
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