Results 181 to 190 of about 304,620 (215)

The P53 Tumor Suppressor Protein

1995
In response to damaged DNA, mammalian cell growth is arrested at cell cycle checkpoints in Gl, near the border of S phase, or in G2, before mitosis (Murray, 1992; Hunter, 1993; Weinert and Lydall, 1993). In some circumstances, DNA damage initiates apoptosis, a program that results in cell death.
Ettore Appella, Kazuyasu Sakaguchi, Hiroshi Sakamoto, Marc S. Lewis, James G. Omichinski, Angela M. Gronenborn, G. Marius Clore, Carl W. Anderson   +7 more
openaire   +1 more source

Association of the APC Tumor Suppressor Protein with Catenins

Science, 1993
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product.
L K, Su, B, Vogelstein, K W, Kinzler
openaire   +2 more sources

The Retinoblastoma Protein: More than a Tumor Suppressor

Annual Review of Cell Biology, 1994
REGULATION OF RB DURING CELL CYCLE PROGRESSION AND DIFFERENTIATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Modification of Rb by Phosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Gl Arrest by Overexpression of Rb . . . . . . . . . . . . . . . . . . . . . . . . .
D J, Riley, E Y, Lee, W H, Lee
openaire   +2 more sources

Interaction of Tumor Suppressor p53 with DNA and Proteins

Current Pharmaceutical Biotechnology, 2010
p53, a tumor suppressor and a transcription factor, binds DNA in a sequence-specific manner. In more than half of human cancers, p53 has been found to be mutated with the loss of DNA-binding ability. In this review, we focus on the sensitive detection of interaction of tumor suppressor p53 with double-stranded DNA bearing the consensus sequence and ...
Jianxiu, Wang, Julei, Yang
openaire   +2 more sources

Stress-activated protein kinases?tumor suppressors or tumor initiators?

Seminars in Cancer Biology, 2004
The biology and the pathology of the stress-activated protein kinases (SAPKs; p38s and c-Jun-NH(2)-terminal kinases (JNKs)) are somewhat confusing. In some systems, these enzymes augment cell proliferation whereas in other cells they support growth arrest and tumor suppressing activity.
openaire   +2 more sources

Functional dissection of p53 tumor suppressor protein

1997
Publisher Summary This chapter discusses the functional dissection of p53 tumor suppressor protein. The p53 tumor suppressor protein plays a pivotal role in tumor suppression and is mutated very frequently in many forms of human cancer. Stress signals such as DNA damage and hypoxia cause the induction and activation of p53 in normal cells with the ...
L, Jayaraman, E, Freulich, C, Prives
openaire   +2 more sources

Inactivation of Tumor Suppressor Proteins in Lung Cancer

American Journal of Respiratory Cell and Molecular Biology, 1996
Abstract It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...
openaire   +2 more sources

p53 Tumor Suppressor Protein Overexpression in Osteogenic Tumors of Dogs

Veterinary Pathology, 1996
Alterations in the p53 tumor suppressor gene have been implicated in the genesis and/or progression of the majority of human cancers, including osteosarcoma. Stabilization of the protein by mutation or interaction with other proteins prolongs its half-life, rendering it detectable by immunohistochemistry.
J E, Sagartz, W L, Bodley, R M, Gamblin, C G, Couto, L A, Tierney, C C, Capen   +5 more
openaire   +2 more sources

Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein

Cancer Research, 2005
Abstract Programmed cell death 4 (Pdcd4) is a tumor suppressor protein that interacts with eukaryotic initiation factor 4A and inhibits protein synthesis. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)–responsive promoters by c-Jun.
PALAMARCHUK A., EFANOV A., MAXIMOV V., AQEILAN R. I., CROCE, Carlo Maria, PEKARSKY Y.   +5 more
openaire   +3 more sources

Investigating the Interaction Between Oncogene and Tumor Suppressor Protein

IEEE Transactions on Information Technology in Biomedicine, 2009
It is known that cancer develops when cells in a part of the body begin to grow out of control. Because cancer cells continue to grow and divide with no order, they never differentiate into the specific tissue, and thus, they are functionally different from normal cells.
Elena Pirogova, Metin Akay, Irena Cosic
openaire   +2 more sources