Results 1 to 10 of about 368,028 (305)

Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting [PDF]

Frontiers in Immunology
IntroductionIn recent years, oncolytic bacterial therapy has emerged as a promising strategy in cancer research due to its unique advantages in tumor targeting and immune activation. Among various bacterial candidates, Salmonella demonstrates exceptional
Bin Yu, Lei Shi, Lei Shi, Lei Shi, Weiwang Duan, Dongmei Cui, Edwin R. Manuel, Wei Huang   +7 more
doaj   +2 more sources

SHP2 regulates VEGFR2 Y1175/PLCγ signaling to impair tumor endothelial barrier stability [PDF]

iScience
Summary: Tumor vasculature is abnormally formed, with an endothelial cell (EC) barrier lacking integrity, resulting in hyperpermeable vessels. Elevated VEGFA levels drive the formation of the dysfunctional vasculature by activating VEGFR2 signaling.
Polina Kremmyda, Sara Owad, Sagnik Pal, Elvira Wildheim, Catarina Chanoca, Cecilia Lindskog, Elin Sjöberg   +6 more
doaj   +2 more sources

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. [PDF]

, 2014
The aim of the present study was to examine the efficacy of tumor-targeting Salmonella typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) therapy on VEGF-positive human pancreatic cancer.
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Matsuyama, Ryusei, Miwa, Shinji, Momiyama, Masashi, Mori, Ryutaro, Murakami, Takashi, Sato, Sho, Tanaka, Kuniya, Yamamoto, Mako, Yano, Shuya, Zhang, Yong, Zhao, Ming   +17 more
core   +21 more sources

Co-Administration of Vadimezan and Recombinant Coagulase-NGR Inhibits Growth of Melanoma Tumor in Mice [PDF]

Advanced Pharmaceutical Bulletin, 2021
Purpose: Tumor vascular targeting appeared as an appealing approach to fight cancer, though, the results from the clinical trials and drugs in the market were proved otherwise.
Amir Daei Farshchi Adli, Rana Jahanban-Esfahlan, Khaled Seidi, Davoud Farajzadeh, Ramezan Behzadi, Nosratollah Zarghami   +5 more
doaj   +1 more source

Nanogold Functionalized With Lipoamide-isoDGR: A Simple, Robust and Versatile Nanosystem for αvβ3-Integrin Targeting

Frontiers in Chemistry, 2021
Gold nanoparticles functionalized with isoDGR, a tripeptide motif that recognizes αvβ3 integrin overexpressed in tumor vessels, have been used as nano-vectors for the delivery of cytokines to tumors.
Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri, Giulia Anderluzzi, Barbara Colombo, Alessandro Gori, Angelo Corti, Angelo Corti, Flavio Curnis   +8 more
doaj   +1 more source

Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides

Pharmaceutics, 2022
Human chromogranin A (CgA), a 439 residue-long member of the “granin” secretory protein family, is the precursor of several peptides and polypeptides involved in the regulation of the innate immunity, cardiovascular system, metabolism, angiogenesis ...
Angelo Corti, Giulia Anderluzzi, Flavio Curnis   +2 more
doaj   +1 more source

Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold

Journal of Nanobiotechnology, 2021
Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature.
Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri, Giulia Anderluzzi, Barbara Colombo, Alessandro Gori, Anna Mondino, Flavio Curnis   +8 more
doaj   +1 more source

Targeting the Blood–Brain Tumor Barrier with Tumor Necrosis Factor-α

Pharmaceutics, 2022
The blood–brain tumor barrier represents a major obstacle for anticancer drug delivery to brain tumors. Thus, novel strategies aimed at targeting and breaching this structure are of great experimental and clinical interest.
Angelo Corti, Teresa Calimeri, Flavio Curnis, Andres J. M. Ferreri   +3 more
doaj   +1 more source

A simple and robust nanosystem for photoacoustic imaging of bladder cancer based on α5β1-targeted gold nanorods

Journal of Nanobiotechnology, 2023
Background Early detection and removal of bladder cancer in patients is crucial to prevent tumor recurrence and progression. Because current imaging techniques may fail to detect small lesions of in situ carcinomas, patients with bladder cancer often ...
Massimo Alfano, Elisa Alchera, Angelina Sacchi, Alessandro Gori, Giacomo Quilici, Irene Locatelli, Chiara Venegoni, Roberta Lucianò, Anna Maria Gasparri, Barbara Colombo, Giulia Taiè, Jithin Jose, Paolo Armanetti, Luca Menichetti, Giovanna Musco, Andrea Salonia, Angelo Corti, Flavio Curnis   +17 more
doaj   +1 more source

Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

Photoacoustics, 2022
Detection and removal of bladder cancer lesions at an early stage is crucial for preventing tumor relapse and progression. This study aimed to develop a new technological platform for the visualization of small and flat urothelial lesions of high-grade ...
Elisa Alchera, Matteo Monieri, Mirko Maturi, Irene Locatelli, Erica Locatelli, Silvia Tortorella, Angelina Sacchi, Angelo Corti, Manuela Nebuloni, Roberta Lucianò, Filippo Pederzoli, Francesco Montorsi, Andrea Salonia, Sandra Meyer, Jithin Jose, Pierangela Giustetto, Mauro Comes Franchini, Flavio Curnis, Massimo Alfano   +18 more
doaj   +1 more source