Results 21 to 30 of about 2,711,825 (248)

Brain Tumor Vascular Network Segmentation from Micro-Tomography [PDF]

, 2011
Micro-tomography produces high resolution images of bio- logical structures such as vascular networks. In this paper, we present a new approach for segmenting vascular network into pathological and normal regions from considering their micro-vessel 3D ...
Raphael Serduc, Xavier Descombes, Boustani, Habdelhakim, Caroline Fonta, Geraldine LeDuc, Leduc, Géraldine, Abdelhakim El Boustani, Serduc, Raphael, Plouraboué, Franck, Descombes, Xavier, Weitkamp, Timm, Timm Weitkamp, Fonta, Caroline, Franck Plouraboue, El Boustani, Abdelhakim   +14 more
core   +1 more source

Targeting Tumor Vascular CD99 Inhibits Tumor Growth

Frontiers in Immunology, 2019
CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker
Elisabeth J. M. Huijbers, Inge M. van der Werf, Lisette D. Faber, Lena D. Sialino, Pia van der Laan, Hanna A. Holland, Anca M. Cimpean, Victor L. J. L. Thijssen, Judy R. van Beijnum, Arjan W. Griffioen   +9 more
doaj   +1 more source

Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro [PDF]

, 2001
Angiogenesis, the formation of a new blood supply, is an essential step in tumorigenesis. Although vascular endothelial growth factor (VEGF) is known to be a very potent angiogenic factor in most solid tumors, little is known about its production and ...
Losa, Marco, Lohrer, P., Gloddek, J., Renner, U., Lohrer, Penny, Uhl, E., Stalla, G., Pagotto, U., Hopfner, Ursula, Renner, Ulrich, Losa, Marc, Losa, M., Pagotto, Uberto, Gloddek, Jutta, Uhl, Eberhard, Stalla, Günter K., Hopfner, U.   +16 more
core   +1 more source

CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma. [PDF]

, 2012
The Salmonella type III secretion system (T3SS) efficiently translocates heterologous proteins into the cytosol of eukaryotic cells. This leads to an antigen-specific CD8 T-cell induction in mice orally immunized with recombinant Salmonella. Recently, we
Jellbauer, Stefan, Hetrodt, Justin H., Justin H Hetrodt, Rüssmann, Holger, Stefan Jellbauer, Klaus Panthel, Holger Rüssmann, Panthel, Klaus   +7 more
core   +2 more sources

Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia. [PDF]

PLoS ONE, 2015
Developed and tested for many years, a variety of tumor hypoxia detection methods have been inconsistent in their ability to predict treatment outcomes or monitor treatment efficacy, limiting their present prognostic capability.
Nathan A Koonce, Joseph Levy, Matthew E Hardee, Azemat Jamshidi-Parsian, Kieng B Vang, Sunil Sharma, James A Raleigh, Ruud P M Dings, Robert J Griffin   +8 more
doaj   +1 more source

Tumor-induced myeloid cell plasticity toward lymphatic endothelium [PDF]

, 2009
Tumor-associated lymphangiogenesis contributes to tumor progression by regulating interstitial fluid pressure, transporting immune cells to the tumor site and providing a route for metastatic dissemination.
Baeriswyl, Vanessa
core   +1 more source

Targeting of Tumor Neovasculature with GrB/VEGF121, a Novel Cytotoxic Fusion Protein

Biomedicines, 2017
Angiogenesis is a critical process in numerous diseases, and intervention in neovascularization has therapeutic value in several disease settings, including ocular diseases, arthritis, and in tumor progression and metastatic spread.
Khalid A. Mohamedali, Michael G. Rosenblum   +1 more
doaj   +1 more source

Immunotherapies targeting tumor vasculature: challenges and opportunities

Frontiers in Immunology, 2023
Angiogenesis is a hallmark of cancer biology, and neoadjuvant therapies targeting either tumor vasculature or VEGF signaling have been developed to treat solid malignant tumors.
Hassan Dianat-Moghadam, Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi, Rasoul Salehi   +7 more
doaj   +1 more source

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

Asian Journal of Pharmaceutical Sciences, 2019
Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells.
Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang, Fengshan Wang   +4 more
doaj   +1 more source

A LIGHTning Strike to the Metastatic Niche

Cell Reports, 2020
Tumor-induced vascular alterations in distant organs have been linked to the spreading of cancer. In this issue of Cell Reports, He et al. (2019) show that targeting the cytokine LIGHT to the pulmonary vasculature prevents the establishment of lung ...
Amaia Martinez-Usatorre, Michele De Palma   +1 more
doaj   +1 more source